Title:
COMPOSITIONS AND METHODS FOR ENHANCING ANTI-VIRAL THERAPIES
Document Type and Number:
WIPO Patent Application WO/2022/185124
Kind Code:
A3
Abstract:
The present disclosure is directed to the use of a uric acid lowering agent (UALA) to increase the effectiveness of interferon in a subject with a viral infection. The UALA may be administered in combination with interferon in a subject undergoing interferon therapy.
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Inventors:
DAVIDOFF ALLEN (CA)
Application Number:
PCT/IB2022/000219
Publication Date:
October 13, 2022
Filing Date:
March 07, 2022
Export Citation:
Assignee:
XORTX THERAPEUTICS INC (CA)
International Classes:
A61K31/375; A61K31/198; A61K38/46; A61P19/06; A61P29/00; A61P31/00; C07C229/26; C07C279/14; C07C323/59; C07D307/62
Foreign References:
| JP2007063284A | 2007-03-15 |
Other References:
PRATOMO IRANDI, ARIANE ANNA, TEDJO ARYO, HERYANTO RUDI, PARAMITA RAFIKA: "Xanthine oxidase inhibition in SARS-CoV-2 infection: the mechanism and potency of allopurinol and febuxostat in COVID-19 management", MEDICAL JOURNAL OF INDONESIA, FACULTY OF MEDICINE UNIVERSITAS INDONESIA, vol. 30, no. 1, 24 November 2020 (2020-11-24), pages 75 - 80, XP009549465, ISSN: 2252-8083, DOI: 10.13181/mji.rev.204641
FONSECA, W. ET AL.: "Uric acid pathway activation during respiratory virus infection promotes Th2 immune response via innate cytokine production and ILC2 accumulation", MUCUSAL IMMUNOLOGY, vol. 13, 11 February 2020 (2020-02-11), pages 691 - 701, XP037162311, DOI: 10.1038/s41385-020-0264-z
ERWAN SALLARD; FRANÇOIS-XAVIER LESCURE; YAZDAN YAZDANPANAH; FRANCE MENTRE; NATHAN PEIFFER-SMADJA: "Type 1 interferons as a potential treatment against COVID-19", ANTIVIRAL RESEARCH, ELSEVIER BV, NL, vol. 178, 1 June 2020 (2020-06-01), NL , pages 1 - 5, XP055768812, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2020.104791
FONSECA, W. ET AL.: "Uric acid pathway activation during respiratory virus infection promotes Th2 immune response via innate cytokine production and ILC2 accumulation", MUCUSAL IMMUNOLOGY, vol. 13, 11 February 2020 (2020-02-11), pages 691 - 701, XP037162311, DOI: 10.1038/s41385-020-0264-z
ERWAN SALLARD; FRANÇOIS-XAVIER LESCURE; YAZDAN YAZDANPANAH; FRANCE MENTRE; NATHAN PEIFFER-SMADJA: "Type 1 interferons as a potential treatment against COVID-19", ANTIVIRAL RESEARCH, ELSEVIER BV, NL, vol. 178, 1 June 2020 (2020-06-01), NL , pages 1 - 5, XP055768812, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2020.104791
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