Title:
COMPOSITIONS AND METHODS FOR INHIBITING TUMOR GROWTH AND METASTASIS
Document Type and Number:
WIPO Patent Application WO2004054517
Kind Code:
A3
Abstract:
Disclosed are compositions and methods useful in the reduction of p11 protein activity in cancer cells. P11 protein is demonstrated to affect plasmin production and activity, MMP activity, plasminogen activation, antiangiogenic plasmin fragment production, cell invasion, tumor development and metastasis. Compositions that modulate levels of p11 either up or down are demonstrated to be effective in reducing tumor development. Also disclosed are cancer treatment methods that employ compositions that modulate p11 activity and clonal cell lines and assays useful for the identification of compositions that modulate p11 activity.
Inventors:
WAISMAN DAVID (CA)
Application Number:
PCT/US2003/040029
Publication Date:
December 28, 2006
Filing Date:
December 12, 2003
Export Citation:
Assignee:
MEDIOMICS LLC (US)
WAISMAN DAVID (CA)
WAISMAN DAVID (CA)
International Classes:
C12N1/20; A01N43/04; C07H21/02; C07H21/04; C12N9/64; C12N15/00; C12N15/113; A01N37/18; C07K1/00; C12N9/00
Other References:
WU ET AL, J. BIOL. CHEM., vol. 272, no. 27, July 1997 (1997-07-01), pages 17145 - 17153, XP008086027
DATABASE GENBANK [online] 20 August 2006 (2006-08-20), WU ET AL, XP008093117, accession no. NCBI Database accession no. (NM_02966)
See also references of EP 1581164A4
DATABASE GENBANK [online] 20 August 2006 (2006-08-20), WU ET AL, XP008093117, accession no. NCBI Database accession no. (NM_02966)
See also references of EP 1581164A4
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