Title:
COMPOSITIONS, METHODS AND KITS FOR DETECTING MELANOMA AND MARGINS OF MELANOMA
Document Type and Number:
WIPO Patent Application WO/2012/040318
Kind Code:
A3
Abstract:
Described herein are compositions, methods and kits for detection of melanoma and determination of melanoma margins. The present invention relates to a novel panel of volatile metabolic biomarkers that can be used in the diagnosis of melanoma skin cancer. A novel approach to detect melanoma is based on volatile by-products of altered cancer metabolism. This invention further provides a method for identifying molecules useful in the detection of melanoma and sets a foundation for development of a non-invasive detection technology, a biosensor, for melanoma diagnosis. Uses for this technology include a diagnostic screen that will help clinicians to assess this disease. One advantage provided by the compositions, methods and kits described herein is that metabolites are at the end phase of the genome-transciptome-proteome-metabolome cascade and thus are the most predictive of the cancer phenotype.
Inventors:
ABAFFY TATJANA (US)
DEFAZIO RICHARD ANTHONY (US)
DEFAZIO RICHARD ANTHONY (US)
Application Number:
PCT/US2011/052538
Publication Date:
June 14, 2012
Filing Date:
September 21, 2011
Export Citation:
Assignee:
UNIV MIAMI (US)
ABAFFY TATJANA (US)
DEFAZIO RICHARD ANTHONY (US)
ABAFFY TATJANA (US)
DEFAZIO RICHARD ANTHONY (US)
International Classes:
B01D59/44; C01B32/50; C09K3/00; H01J49/00
Domestic Patent References:
| WO2010079490A1 | 2010-07-15 |
Foreign References:
| US6312390B1 | 2001-11-06 |
Other References:
D'AMICO ET AL.: "Identification of melanoma with a gas sensor array", SKIN RESEARCH AND TECHNOLOGY, vol. 14, 2008, pages 226 - 236
PENG ET AL.: "Detection of lung, breast, colorectal, and prostate cancers from exhaled breath using a single array of nanosensors", BRITISH JOURNAL OF CANCER, vol. 103, no. 4, 20 July 2010 (2010-07-20), pages 542 - 551, Retrieved from the Internet
ABAFFY ET AL.: "Differential Volatile Signatures from Skin, Naevi and Melanoma: A Novel Approach to Detect a Pathological Process", PLOS ONE, vol. 5, no. 11, 1 November 2010 (2010-11-01), pages 1 - 12
PENG ET AL.: "Detection of lung, breast, colorectal, and prostate cancers from exhaled breath using a single array of nanosensors", BRITISH JOURNAL OF CANCER, vol. 103, no. 4, 20 July 2010 (2010-07-20), pages 542 - 551, Retrieved from the Internet
ABAFFY ET AL.: "Differential Volatile Signatures from Skin, Naevi and Melanoma: A Novel Approach to Detect a Pathological Process", PLOS ONE, vol. 5, no. 11, 1 November 2010 (2010-11-01), pages 1 - 12
Attorney, Agent or Firm:
DOBBELAERE, Amy A. (525 Okeechobee Blvd.West Palm Beach, Florida, US)
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