Title:
COMPOSITIONS, METHODS AND KITS FOR ENHANCING THE IMMUNOGENICITY OF A BACTERIAL VACCINE VECTOR
Document Type and Number:
WIPO Patent Application WO2004062597
Kind Code:
A3
Abstract:
The present invention comprises methods for enhancing the immunogenicity of a bacterial vaccine vector and an antigen by passaging the bacterial vaccine vector through an animal.
Inventors:
PATERSON YVONNE (US)
PETERS CHRISTIAN (US)
PETERS CHRISTIAN (US)
Application Number:
PCT/US2004/000366
Publication Date:
January 12, 2006
Filing Date:
January 08, 2004
Export Citation:
Assignee:
UNIV PENNSYLVANIA (US)
PATERSON YVONNE (US)
PETERS CHRISTIAN (US)
PATERSON YVONNE (US)
PETERS CHRISTIAN (US)
International Classes:
A61K31/00; A61K39/00; A61K39/02; A61M1/00; A61P31/00; C07K14/025; C07K14/16; A61K; (IPC1-7): C12N1/21
Domestic Patent References:
| WO2001025399A2 | 2001-04-12 |
Foreign References:
| US3328252A | 1967-06-27 | |||
| US20020177569A1 | 2002-11-28 |
Other References:
FOLEY J E ET AL: "'Candidatus Mycoplasma haemominutum', a low-virulence epierythrocytic parasite of cats.", INT J SYST EVOL MICROBIOL., vol. 51, no. 3, May 2001 (2001-05-01), pages 815 - 817, XP003014626
MANKOSKI R ET AL: "flaA mRNA transcription level correlates with Helicobacter pylori colonisation efficiency in gnotobiotic piglets.", J MED MICROBIOL., vol. 48, no. 4, April 1999 (1999-04-01), pages 395 - 399, XP008082973
SHEN H ET AL: "Recombinant Listeria monocytogenes as a live vaccine vehicle for the induction of protective anti-viral cell-mediated immunity.", PROC NATL ACAD SCI U S A., vol. 92, no. 9, April 1995 (1995-04-01), pages 3987 - 3991, XP002338965
MERINO D ET AL: "A hypermutator phenotype attenuates the virulence of Listeria monocytogenes in a mouse model.", MOLECULAR MICROBIOLOGY., vol. 44, no. 3, May 2002 (2002-05-01), pages 877 - 887, XP002320924
KLEANTHOUS H ET AL: "Sterilizing immunity against experimental Helicobacter pylori infection is challenge-strain dependent.", VACCINE., vol. 19, no. 32, 14 September 2001 (2001-09-14), pages 4883 - 4895, XP004303186
MANKOSKI R ET AL: "flaA mRNA transcription level correlates with Helicobacter pylori colonisation efficiency in gnotobiotic piglets.", J MED MICROBIOL., vol. 48, no. 4, April 1999 (1999-04-01), pages 395 - 399, XP008082973
SHEN H ET AL: "Recombinant Listeria monocytogenes as a live vaccine vehicle for the induction of protective anti-viral cell-mediated immunity.", PROC NATL ACAD SCI U S A., vol. 92, no. 9, April 1995 (1995-04-01), pages 3987 - 3991, XP002338965
MERINO D ET AL: "A hypermutator phenotype attenuates the virulence of Listeria monocytogenes in a mouse model.", MOLECULAR MICROBIOLOGY., vol. 44, no. 3, May 2002 (2002-05-01), pages 877 - 887, XP002320924
KLEANTHOUS H ET AL: "Sterilizing immunity against experimental Helicobacter pylori infection is challenge-strain dependent.", VACCINE., vol. 19, no. 32, 14 September 2001 (2001-09-14), pages 4883 - 4895, XP004303186
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