Title:
COMPOSITIONS AND METHODS FOR LABELING AND DETECTING BINDING PARTNERS
Document Type and Number:
WIPO Patent Application WO/2024/030455
Kind Code:
A3
Abstract:
Disclosed are compositions comprising a ligandable tag, a linker, and a labeling enzyme, wherein the linker attaches the ligandable tag to the labeling enzyme. Disclosed are nucleic acid sequences capable of encoding one or more of the disclosed protein based compositions. Disclosed are compositions comprising a ligand conjugated to a molecule of interest. Disclosed are systems comprising a labeling composition and a targeting composition, wherein the labeling composition comprises a ligandable tag, a linker, and a labeling enzyme, wherein the linker attaches the ligandable tag to the labeling enzyme, wherein the targeting composition comprises a ligand conjugated to a molecule of interest, wherein the ligand of the targeting composition is a ligand for the ligandable tag of the labeling composition. Disclosed are methods of using the disclosed compositions and systems.
Inventors:
ENGLISH JUSTIN (US)
FERGUSON FLEUR (US)
FERGUSON FLEUR (US)
Application Number:
PCT/US2023/029251
Publication Date:
March 14, 2024
Filing Date:
August 01, 2023
Export Citation:
Assignee:
UNIV UTAH RES FOUND (US)
UNIV CALIFORNIA (US)
UNIV CALIFORNIA (US)
International Classes:
C07K1/13; G01N33/58; G01N33/48
Foreign References:
| US11299526B2 | 2022-04-12 | |||
| US20210189432A1 | 2021-06-24 |
Other References:
JONATHAN LOTZE, ULRIKE REINHARDT, OLIVER SEITZ, ANNETTE G. BECK-SICKINGER: "Peptide-tags for site-specific protein labelling in vitro and in vivo", MOLECULAR BIOSYSTEMS, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 12, no. 6, 1 January 2016 (2016-01-01), GB , pages 1731 - 1745, XP055340848, ISSN: 1742-206X, DOI: 10.1039/C6MB00023A
LIU FEI, DANYLCHUK DMYTRO I., ANDREIUK BOHDAN, KLYMCHENKO ANDREY S.: "Dynamic covalent chemistry in live cells for organelle targeting and enhanced photodynamic action", CHEMICAL SCIENCE, ROYAL SOCIETY OF CHEMISTRY, UNITED KINGDOM, vol. 13, no. 13, 30 March 2022 (2022-03-30), United Kingdom , pages 3652 - 3660, XP093149122, ISSN: 2041-6520, DOI: 10.1039/D1SC04770A
LIU FEI, DANYLCHUK DMYTRO I., ANDREIUK BOHDAN, KLYMCHENKO ANDREY S.: "Dynamic covalent chemistry in live cells for organelle targeting and enhanced photodynamic action", CHEMICAL SCIENCE, ROYAL SOCIETY OF CHEMISTRY, UNITED KINGDOM, vol. 13, no. 13, 30 March 2022 (2022-03-30), United Kingdom , pages 3652 - 3660, XP093149122, ISSN: 2041-6520, DOI: 10.1039/D1SC04770A
Attorney, Agent or Firm:
SCIASCIA-ZIRGER, Sandra et al. (US)
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