COMPOSITIONS AND METHODS FOR MEASURING BLOOD GLUCOSE LEVELS

Title:

COMPOSITIONS AND METHODS FOR MEASURING BLOOD GLUCOSE LEVELS

Document Type and Number:

WIPO Patent Application WO/2016/087937

Kind Code:

A3

Abstract:

The present invention provides a protein comprising amino acids in the following sequence L(X)n= 14X 3 (X)n= 1X1 )n=,E(X)n-4P(X) n=1NR(X)n=3S(X)n=4D(X)n=2G(X)n=7Y(X)n=4 (X)n= 32 3 4 X2, wherein each X independently represents any naturally occurring amino acid residue and n indicates the number of amino acid residues represented by the respective paranthetical at that position, wherein: a) X1 is selected from the group consisting of S, C, T, M, V, Y, N, P, L, G, Q, A, I, D, W, H, or E, wherein if X1 is L, H or V, then X3 is D; and/or b) X2 is selected from the group consisting of H, L, S or V. In some embodiments, the present invention also provides a protein comprising amino acids in the sequence set forth by SEQ ID NO: 38 or SEQ ID NO: 39, except that: the amino acid at position 406 is an amino acid other than F.

Inventors:

GUTTMAN CHEN HAIM (IL)
BARAM DAVID (IL)
GOFBERG ITAMAR OZ (IL)
OMER DOTAN (IL)

Application Number:

PCT/IB2015/002431

Publication Date:

March 09, 2017

Filing Date:

December 04, 2015

Export Citation:

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Assignee:

SMARTZYME INNOVATION LTD (IL)

International Classes:

C12N9/02; C12Q1/54

Foreign References:

US20040023330A1	2004-02-05
US20120107903A1	2012-05-03
US20110076707A1	2011-03-31
US20080206833A1	2008-08-28

Other References: