Title:
COMPOSITIONS AND METHODS FOR NANOHISTOLOGY
Document Type and Number:
WIPO Patent Application WO/2024/054662
Kind Code:
A3
Abstract:
Atomic force microscopy (AFM) can be used to image biological samples with low nanomolar resolution. Compared to other imaging modalities with nanoscale resolution, AFM does not require the use of complex, costly instrumentation or toxic heavy metals to image samples. The ability of AFM to access interior structures of a sample cross-section in nanohistology applications in a controlled and automated manner is limited with conventional AFM sample preparation methodology. The present disclosure provides methods and compositions for preparing a sample for nanohistology. The methods and compositions disclosed herein can prepare a sample for nanohistology that preserve the structure of biological molecules in a sample, allowing for serial cross-sectional imaging of the sample.
Inventors:
BUSER CHRISTOPHER (US)
Application Number:
PCT/US2023/032343
Publication Date:
April 18, 2024
Filing Date:
September 08, 2023
Export Citation:
Assignee:
BIOCUBIC LLC (US)
International Classes:
A01N1/02; G01N1/42
Attorney, Agent or Firm:
DANIELS, Jacob (US)
Download PDF: