COMPOSITIONS AND METHODS FOR OPTIMIZING UGT2B7 SUBSTRATE DOSINGS AND FOR PREDICTING UGT2B7 SUBSTRATE TOXICITY

Title:

COMPOSITIONS AND METHODS FOR OPTIMIZING UGT2B7 SUBSTRATE DOSINGS AND FOR PREDICTING UGT2B7 SUBSTRATE TOXICITY

Document Type and Number:

WIPO Patent Application WO2002059375

Kind Code:

A9

Abstract:

This invention concerns UGT2B7 and its ability to gluronidate various drugs, including epirubicin. It concerns methods and compositions for determining the level of UGT2B7 activity based on genetic composition, and consequently, allows dosing of UTG2B7-glucuronidated drugs to be improved or optimized based on a patient's level of predicted UGT2B7 activity. It further concerns methods of treatment in which UGT2B7 substrates are administered to patients as part of a treatment regimen.

Inventors:

RATAIN MARK J (US)
INNOCENTI FEDERICO (US)
DAS SOMA (US)
IYER LALITHA (US)
SAWYER MICHAEL (CA)

Application Number:

PCT/US2002/002083

Publication Date:

October 31, 2002

Filing Date:

January 25, 2002

Export Citation:

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Assignee:

UNIV CHICAGO (US)
RATAIN MARK J (US)
INNOCENTI FEDERICO (US)
DAS SOMA (US)
IYER LALITHA (US)
SAWYER MICHAEL (CA)

International Classes:

A61K31/70; C12Q1/68; C12Q1/6827; C12Q1/6883; (IPC1-7): C12Q1/68

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