Title:
COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING NEURODEGENERATIVE DISEASES
Document Type and Number:
WIPO Patent Application WO/2023/248206
Kind Code:
A1
Abstract:
The present invention provides a composition for preventing or treating a neurodegenerative disease containing a phosphodiesterase 5 inhibitor (PDE5 inhibitors) and an acetylcholinesterase inhibitor (AChEI) and a method using thereof, wehrein the PDE5 inhibitor is selected from among mirodenafil, sildenafil, vardenafil, tadalafil, udenafil, dasantafil, avanafil, pharmaceutically acceptable salts, solvates, hydrates, and a mixture thereof; and the AchEI is selected from among donepezil, rivastigmine, galantamine, physostigmine, tacrine, metrifonate, phenserine, tolserine, eseroline, huperizine A and B, galangin, cardanol, donepezil-AP2238, donepezil-tacrine, tacrine-ferulic acid hybrid, tacrine-hydroxyquinoline, ladostigil, indenyl derivatives, pharmaceutically acceptable salts, solvates, hydrates and a mixture thereof; and the neurodegenerative disease is dementia, Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD) or Multiple sclerosis (MS).
Inventors:
CHOUNG JAI JUN (KR)
SEO BO SEUNG (KR)
KANG BYUNGWOO (KR)
SEO BO SEUNG (KR)
KANG BYUNGWOO (KR)
Application Number:
PCT/IB2023/056532
Publication Date:
December 28, 2023
Filing Date:
June 24, 2023
Export Citation:
Assignee:
ARIBIO CO LTD (US)
International Classes:
A61K31/519; A61K31/27; A61K31/445; A61K31/55; A61K45/06; A61P25/28
Domestic Patent References:
| WO2008144061A2 | 2008-11-27 |
Foreign References:
| KR102271305B1 | 2021-06-30 | |||
| US20210052528A1 | 2021-02-25 | |||
| US20100048726A1 | 2010-02-25 | |||
| US20170326145A1 | 2017-11-16 |
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