Title:
COMPOSITIONS AND METHODS FOR PROLONGING SURVIVAL OF PLATELETS
Document Type and Number:
WIPO Patent Application WO2004043381
Kind Code:
A3
Abstract:
The present invention provides modified platelets having a reduced platelet clearance and methods for reducing platelet clearance. Also provided are compositions for the preservation of platelets. The invention also provides methods for making a pharmaceutical composition containing the modified platelets and for administering the pharmaceutical composition to a mammal to mediate hemostasis.
Inventors:
STOSSEL THOMAS P
HARTWIG JOHN H
HOFFMEISTER KARIN M
CLAUSEN HENRIK
HARTWIG JOHN H
HOFFMEISTER KARIN M
CLAUSEN HENRIK
Application Number:
PCT/US2003/035629
Publication Date:
January 27, 2005
Filing Date:
November 07, 2003
Export Citation:
Assignee:
BRIGHAM & WOMENS HOSPITAL (US)
ZYMEQUEST INC (US)
ZYMEQUEST INC (US)
International Classes:
A01N1/02; A61K31/7072; A61K38/47; C12N5/07; C12N5/078; C12N5/0786; (IPC1-7): A01N1/02
Foreign References:
| US5089146A | 1992-02-18 |
Other References:
KARPATKIN S. ET AL: "Glycogenesis and Glyconeogenesis in Human Platelets. INCORPORATION OF GLUCOSE, PYRUVATE, AND CITRATE INTO PLATALET GLYCOGEN; GLYCOGEN SYNTHETASE AND FRUCTOSE-1,6-DIPHOSPHATASE ACTIVITY", JOURNAL OF CLINICAL INVESTIGATION, vol. 49, no. 1, 1970, pages 140 - 149, XP002903507
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