Title:
COMPOSITIONS AND METHODS FOR PROMOTING MYOCARDIAL AND PERIPHERAL ANGIOGENESIS
Document Type and Number:
WIPO Patent Application WO2003059436
Kind Code:
A3
Abstract:
Methods, compositions and devices are disclosed for use in growing new blood vessels to restore or improve blood flow to ischemic tissues and organs of the body. Compositions comprising IGD peptides, particularly GGIGDGG, are able to induce migration in human endothelial cells and promote vessel formation in an in vitro model assay system.
Inventors:
AKELLA RAMA
RANIERI JOHN
RANIERI JOHN
Application Number:
PCT/US2002/041484
Publication Date:
September 23, 2004
Filing Date:
December 23, 2002
Export Citation:
Assignee:
CT PULSE BIOLOG INC (US)
International Classes:
A61K47/32; A61K38/00; A61K38/18; A61K38/19; A61K38/22; A61P9/00; A61P9/10; C07K5/08; C07K5/083; C07K5/10; C07K5/103; C07K7/06; C07K14/78; (IPC1-7): A61K38/06; A61K38/08; A61K38/18; A61K49/00; C07K11/00
Domestic Patent References:
| WO1999002674A1 | 1999-01-21 |
Foreign References:
| US6468960B1 | 2002-10-22 | |||
| US20020040004A1 | 2002-04-04 |
Other References:
CHERNOUSOV M. ET AL: "Role of the I-9 and III-1 modules of fibronectin in formation of an extracellular fibronectin matrix", J. BIOL. CHEM., vol. 266, no. 17, 15 June 1991 (1991-06-15), pages 10851 - 10858, XP002197279
See also references of EP 1478383A4
See also references of EP 1478383A4
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