Title:
COMPOSITIONS AND METHODS FOR PROMOTINGGLYCOGEN SYNTHASE ACTIVITY AND AUGMENTING GLYCOGEN STORAGE CAPABILITY
Document Type and Number:
WIPO Patent Application WO/2022/218320
Kind Code:
A1
Abstract:
The present invention provides compositions and methods for promoting glycogen synthase activity and augmenting glycogen storage capability in muscle tissue and/or liver tissue in a mammal, relating to administration to the mammal of an effective amount of β‐aminoisobutyric acid (BAIBA), an analog or derivative thereof, or a pharmaceutically acceptable salt, ester, acid, polymer, analog or derivative thereof.
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Inventors:
WANG MINGRU (CN)
FAN QIRU (CN)
WANG OU (CN)
YI RONGHUA (CN)
LIAO KYLIN (CN)
FAN QIRU (CN)
WANG OU (CN)
YI RONGHUA (CN)
LIAO KYLIN (CN)
Application Number:
PCT/CN2022/086514
Publication Date:
October 20, 2022
Filing Date:
April 13, 2022
Export Citation:
Assignee:
NANJING NUTRABUILDING BIO TECH CO LTD (CN)
International Classes:
A61P21/00; A61K31/197
Domestic Patent References:
| WO2004091598A1 | 2004-10-28 |
Foreign References:
| US20220054441A1 | 2022-02-24 |
Other References:
ARNAUD BAQUET ET AL.: "Comparison of the effects of various amino acids on glycogen synthesis， lipogenesis and ketogenesis in isolated rat hepatocytes", BIOCHEM.J., vol. 273, 31 December 1991 (1991-12-31), XP000566718
LEE D. ROBERTS, PONTUS BOSTRöM, JOHN F. O’SULLIVAN, ROBERT T. SCHINZEL, GREGORY D. LEWIS, ANDRE DEJ: "β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors", CELL METABOLISM, CELL PRESS, UNITED STATES, vol. 19, no. 1, 1 January 2014 (2014-01-01), United States , pages 96 - 108, XP055529936, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2013.12.003
YUKIKO KITASE, JULIAN A VALLEJO, WILLIAM GUTHEIL , HARIKA VEMULA , KATHARINA JäHN , JIANXUN YI , JINGSONG ZHOU , MARCO BROTTO: "β-aminoisobutyric Acid, l-BAIBA, Is a Muscle-Derived Osteocyte Survival Factor", CELL REPORTS, vol. 22, no. 6, 6 February 2018 (2018-02-06), pages 1531 - 1544, XP055815187
DMITRII TANIANSKII, NATALIA JARZEBSKA, ANDREAS BIRKENFELD, JOHN O’SULLIVAN, ROMAN RODIONOV: "Beta-Aminoisobutyric Acid as a Novel Regulator of Carbohydrate and Lipid Metabolism", NUTRIENTS, vol. 11, no. 3, pages 524, XP055679570, DOI: 10.3390/nu11030524
LEE D. ROBERTS, PONTUS BOSTRöM, JOHN F. O’SULLIVAN, ROBERT T. SCHINZEL, GREGORY D. LEWIS, ANDRE DEJ: "β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors", CELL METABOLISM, CELL PRESS, UNITED STATES, vol. 19, no. 1, 1 January 2014 (2014-01-01), United States , pages 96 - 108, XP055529936, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2013.12.003
YUKIKO KITASE, JULIAN A VALLEJO, WILLIAM GUTHEIL , HARIKA VEMULA , KATHARINA JäHN , JIANXUN YI , JINGSONG ZHOU , MARCO BROTTO: "β-aminoisobutyric Acid, l-BAIBA, Is a Muscle-Derived Osteocyte Survival Factor", CELL REPORTS, vol. 22, no. 6, 6 February 2018 (2018-02-06), pages 1531 - 1544, XP055815187
DMITRII TANIANSKII, NATALIA JARZEBSKA, ANDREAS BIRKENFELD, JOHN O’SULLIVAN, ROMAN RODIONOV: "Beta-Aminoisobutyric Acid as a Novel Regulator of Carbohydrate and Lipid Metabolism", NUTRIENTS, vol. 11, no. 3, pages 524, XP055679570, DOI: 10.3390/nu11030524
Attorney, Agent or Firm:
BEIJING DINGJIADA IP FIRM (CN)
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