Title:
COMPOSITIONS AND METHODS RELATED TO THE MINN1 TUMOR SUPPRESSOR GENE AND PROTEIN
Document Type and Number:
WIPO Patent Application WO2002046223
Kind Code:
A3
Abstract:
The present invention relates to Ras signalling effector proteins, tumor suppressors and apoptosis. Specifically, the present invention relates to the Ras effector and tumor suppressor gene and protein Minn1 and the regulation/induction of apoptosis. The invention provides compositions and methods for the treatment of cancer, and also relates to the analysis of Minn1 gene structure, transcription and expression.
Inventors:
CLARK GEOFF (US)
VOS MICHELE (US)
VOS MICHELE (US)
Application Number:
PCT/US2001/048514
Publication Date:
January 16, 2003
Filing Date:
December 07, 2001
Export Citation:
Assignee:
US GOV REPRESENTED BY THE DEPT (US)
CLARK GEOFF (US)
VOS MICHELE (US)
CLARK GEOFF (US)
VOS MICHELE (US)
International Classes:
C07K14/47; C12N15/12; C12Q1/68; C12Q1/6886; A61K48/00; (IPC1-7): C07K14/47; A61K48/00; C07K16/18; C12N15/12; C12Q1/68; G01N33/53
Domestic Patent References:
| WO1999002701A1 | 1999-01-21 |
Other References:
VOS MICHELE D ET AL: "Accelerated publication: Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosis.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 46, 17 November 2000 (2000-11-17), pages 35669 - 35672, XP002208463, ISSN: 0021-9258
DAMMANN REINHARD ET AL: "Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3.", NATURE GENETICS, vol. 25, no. 3, AF132676, July 2000 (2000-07-01), pages 315 - 319, XP002208464, ISSN: 1061-4036
DAMMANN REINHARD ET AL: "Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3.", NATURE GENETICS, vol. 25, no. 3, AF132676, July 2000 (2000-07-01), pages 315 - 319, XP002208464, ISSN: 1061-4036
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