COMPOSITIONS AND METHODS FOR RESTORING SENSITIVITY OF TUMOR CELLS TO ANTITUMOR THERAPY AND INDUCING APOPTOSIS

Title:

COMPOSITIONS AND METHODS FOR RESTORING SENSITIVITY OF TUMOR CELLS TO ANTITUMOR THERAPY AND INDUCING APOPTOSIS

Document Type and Number:

WIPO Patent Application WO2005000240

Kind Code:

A3

Abstract:

Methods and compositions for restoring sensitivity to the antitumorigenic effects of antiestrogen therapy and/or cytotoxic therapy and inducing cell apoptosis are provided. Contacting tumor cells to GP88 antagonists (e.g., anti-GP88 antibodies, anti-GP88 antisense nucleic acids, GP88 siRNA, and small molecules) induces apoptosis and restores sensitivity to the antitumorigenic effects of antiestrogen therapy and cytotoxic therapy.

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Inventors:

SERRERO GINETTE (US)

Application Number:

PCT/US2004/020036

Publication Date:

November 03, 2005

Filing Date:

June 23, 2004

Export Citation:

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Assignee:

A & G PHARMACEUTICAL INC (US)
SERRERO GINETTE (US)

International Classes:

A01N33/02; A61K31/135; A61K31/137; A61K31/56; A61K39/395; A61P35/00; A61K; (IPC1-7): A61K39/395; A01N33/02; A61K31/135; A61K31/56

Foreign References:

US20020025543A1	2002-02-28
US6309826B1	2001-10-30
US5725853A	1998-03-10

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