COMPOSITIONS AND METHODS FOR THE SELF-INACTIVATION OF BASE EDITORS

Title:

COMPOSITIONS AND METHODS FOR THE SELF-INACTIVATION OF BASE EDITORS

Document Type and Number:

WIPO Patent Application WO/2022/251687

Kind Code:

A3

Abstract:

Disclosed herein are polynucleotides encoding a deaminase or napDNAbp polypeptide comprising an intron inserted in an open-reading frame encoding the deaminase or napDNAbp, further wherein the intron has an altered splice acceptor or splice donor site which functions to decrease splicing of editing mRNA. Also disclosed are polynucleotides encoding a base editor open reading frame comprising an intron, wherein the base editor comprises a napDNAbp domain or a deaminase domain

Inventors:

BRYSON DAVID (US)
SULLIVAN JACK (US)

Application Number:

PCT/US2022/031419

Publication Date:

January 19, 2023

Filing Date:

May 27, 2022

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Assignee:

BEAM THERAPEUTICS INC (US)

International Classes:

A61K31/70; C12N15/10; C12N15/11; C12N15/90; A61K38/46

Domestic Patent References:

WO2019217943A1	2019-11-14
WO2019113310A1	2019-06-13

Foreign References:

US20180073012A1

2018-03-15

Attorney, Agent or Firm:

HUNTER-ENSOR, Melissa (US)

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