Title:
COMPOSITIONS AND METHODS FOR STIMULATING MAGP-1 TO IMPROVE THE APPEARANCE OF SKIN
Document Type and Number:
WIPO Patent Application WO/2012/005876
Kind Code:
A3
Abstract:
The present disclosure relates to methods for treating, preventing and improving the condition and aesthetic appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, by application of one or a combination of natural compounds or extracts that stimulate MAGP-1 expression and which improves the appearance of aged and/or photodamaged skin. The compositions of the invention are topically applied to the skin, or are delivered by directed means to a site in need thereof in an amount effective to improve the condition and aesthetic appearance of skin.
Inventors:
ZHENG QIAN (US)
CHEN SIMING W (US)
SANTHANAM UMA (US)
LYGA JOHN W (US)
CHEN SIMING W (US)
SANTHANAM UMA (US)
LYGA JOHN W (US)
Application Number:
PCT/US2011/040157
Publication Date:
March 15, 2012
Filing Date:
June 13, 2011
Export Citation:
Assignee:
AVON PROD INC (US)
ZHENG QIAN (US)
CHEN SIMING W (US)
SANTHANAM UMA (US)
LYGA JOHN W (US)
ZHENG QIAN (US)
CHEN SIMING W (US)
SANTHANAM UMA (US)
LYGA JOHN W (US)
International Classes:
C12N5/00
Foreign References:
| US20080274453A1 | 2008-11-06 | |||
| US20070161625A1 | 2007-07-12 | |||
| US20090012273A1 | 2009-01-08 |
Other References:
DATABASE GENBANK 15 December 2009 (2009-12-15), FARACO ET AL.: "RecName: Full=Microfibrillar-associated protein 2; Short=MFAP-2; AltName: Full=Microfibrilassociated glycoprotein 1; Short=MAGP; Short=MAGP-1; Flags: Precursor.", XP008162517, Database accession no. P55001
WEINBAUM ET AL.: "Deficiency in microfibril-associated glycoprotein-1 leads to complex phenotypes in multiple organ systems.", J. BIOL. CHEM., vol. 283, no. 37, 12 September 2008 (2008-09-12), pages 25533 - 25543, XP008162542
WEINBAUM ET AL.: "Deficiency in microfibril-associated glycoprotein-1 leads to complex phenotypes in multiple organ systems.", J. BIOL. CHEM., vol. 283, no. 37, 12 September 2008 (2008-09-12), pages 25533 - 25543, XP008162542
Attorney, Agent or Firm:
ZELLER, Charles J. (Inc.Avon Plac, Suffern New York, US)
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