COMPOSITIONS AND METHODS FOR TARGETED BIOLOGICAL DELIVERY OF MOLECULAR CARRIERS

Title:

COMPOSITIONS AND METHODS FOR TARGETED BIOLOGICAL DELIVERY OF MOLECULAR CARRIERS

Document Type and Number:

WIPO Patent Application WO2004062602

Kind Code:

A3

Abstract:

The present invention relates generally to compositions adapted to provide delivery of therapeutic, diagnostic, prophylactic, or imaging molecules across polarized cells, and methods of their use. By associating two or more targeting elements in or with the composition, one of which binds to a first cell surface component, and another that binds to a second component of the cell that is not initially available to the composition in an amount sufficient to promote effective delivery of all or a portion of the composition into and/or across polarized cells, the compositions of the present invention can provide enhanced bioavailability of medically-relevant moieties.

Inventors:

SHERIDAN PHILIP LEE (US)
CHAPIN STEVEN J (US)
DOMINGO DERRICK (US)

Application Number:

PCT/US2004/000444

Publication Date:

December 16, 2004

Filing Date:

January 09, 2004

Export Citation:

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Assignee:

ARIZEKE PHARMACEUTICALS INC (US)
SHERIDAN PHILIP LEE (US)
CHAPIN STEVEN J (US)
DOMINGO DERRICK (US)

International Classes:

A61K38/00; A61K47/48; C07K16/28; C12N5/00; C12N15/85; A61K; (IPC1-7): A61K38/00; C12N5/00

Domestic Patent References:

WO2002074787A2

2002-09-26

Foreign References:

US6072041A	2000-06-06
US20020102657A1	2002-08-01
US6042833A	2000-03-28

Other References: