COMPOSITIONS AND METHODS TO PREVENT AND TREAT BIOFILMS

Title:

COMPOSITIONS AND METHODS TO PREVENT AND TREAT BIOFILMS

Document Type and Number:

WIPO Patent Application WO/2012/173796

Kind Code:

A3

Abstract:

Compositions and methods to treat biofilms are disclosed based on the discovery of the role of the disaccharide trehalose in microbial biofilm development. In various embodiments to treat body-borne biofilms systemically and locally, the method includes administering trehalase, the enzyme which degrades trehalose, in combination with other saccharidases for an exposition time sufficient to adequately degrade the biofilm gel matrix at the site of the biofilm. The method also includes administering a combination of other enzymes such as proteolytic, fibrinolytic, and lipolytic enzymes to break down proteins and lipids present in the biofilm, and administering antimicrobials for the specific type(s) of infectious pathogen(s) underlying the biofilm. Additionally, methods are disclosed to address degradation of biofilms on medical device surfaces and biofilms present in industrial settings.

Inventors:

IVANOVA SVETLANA A (US)
DAVIS DENNIS W (US)
ARENZ BRAD W (US)
CONNELLAN THOMAS K (US)

Application Number:

PCT/US2012/040408

Publication Date:

May 02, 2013

Filing Date:

June 01, 2012

Export Citation:

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Assignee:

IVANOVA SVETLANA A (US)
DAVIS DENNIS W (US)
ARENZ BRAD W (US)
CONNELLAN THOMAS K (US)

International Classes:

A61L2/16; A01N63/50; A61F2/20; A61F2/24; A61L27/00

Domestic Patent References:

WO2006032011A2

2006-03-23

Foreign References:

US20110129454A1	2011-06-02
US6759040B1	2004-07-06
US20060121019A1	2006-06-08
US20090202516A1	2009-08-13
EP0820516B1	2002-03-06

Other References: