COMPOSITIONS AND METHODS FOR TRAPPING AND INACTIVATING PATHOGENIC MICROBES AND SPERMATOZOA

Title:

COMPOSITIONS AND METHODS FOR TRAPPING AND INACTIVATING PATHOGENIC MICROBES AND SPERMATOZOA

Document Type and Number:

WIPO Patent Application WO2001066084

Kind Code:

A3

Abstract:

Antimicrobial and contraceptive compositions and methods which prevent and/or reduce the risk of transmission of sexually transmitted diseases through sexual activity as well as prevent and/or reduce the risk of pregnancy are provided. The compositions contain (1) a matrix-forming agent, (2) a bio-adhesive agent, (3) a buffering agent, (4) optionally a humectant, (5) optionally a preservative, and (6) water; wherein the composition is suitable for application within the vagina; wherein the compositions form a semisolid matrix on contact with ejaculate (thereby trapping ejaculated microbes and spermatozoa); wherein the composition causes hardening of cervical mucus (thereby decreasing the probability of sperm entry); wherein the composition forms a bio-adhesive layer over vaginal surfaces (thereby preventing or reducing the risk of contact of STD-causing microbes with the vaginal surfaces); wherein the composition maintains an acidic vaginal pH of less than about 5 in the presence of semen ejaculated from the male; and wherein the composition does not significantly impair the natural microbiological balance within the vagina. The antimicrobial and contraceptive compositions may also contain additional antimicrobial and/or contraceptive agents (e.g., nonoxynol-9, octoxynol-9, benzalkonium chloride, phosphorylated hesperidins, sulfonated hesperidins, polystyrene sulfonates, substituted benzenesulfonic acid formaldehyde co-polymers, H>24<-modified mandelic acids, povidone iodine, itraconazole, ketoconazole, metronidazole, clotrimazole, fluconazole, teraconazole, miconazole, tinidazole, iconazole, chloramphenicol, nystatin, cyclopiroxolamine, and the like).

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Inventors:

GARG SANJAY (US)
ZANEVELD LOURENS JAN DIRK (US)
ANDERSON ROBERT ANTHONY JR (US)
WALLER DONALD PAUL (US)

Application Number:

PCT/US2001/007042

Publication Date:

February 28, 2002

Filing Date:

March 06, 2001

Export Citation:

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Assignee:

RUSH PRESBYTERIAN ST LUKE (US)
GARG SANJAY (US)
ZANEVELD LOURENS JAN DIRK (US)
ANDERSON ROBERT ANTHONY JR (US)
WALLER DONALD PAUL (US)

International Classes:

A61K9/00; A61K31/00; A61K31/085; A61K31/14; A61K31/192; A61K31/7048; A61K31/795; A61K47/10; A61K47/12; A61K47/36; A61K47/18; (IPC1-7): A61K9/06; A61K9/20; A61P15/18; A61K9/00

Domestic Patent References:

WO1996010989A1	1996-04-18
WO1996019195A1	1996-06-27
WO1997047310A1	1997-12-18
WO1997042962A1	1997-11-20
WO1992016182A2	1992-10-01
WO1996000543A1	1996-01-11
WO2000056366A1	2000-09-28

Foreign References:

EP0255902A1	1988-02-17
EP0359402A2	1990-03-21
EP0231816A2	1987-08-12
EP0351301A2	1990-01-17

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