Title:
COMPOSITIONS AND METHODS FOR TREATING ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) AND INFLAMMATORY DISORDERS CAUSED BY CORONAVIRUSES
Document Type and Number:
WIPO Patent Application WO/2021/243007
Kind Code:
A3
Abstract:
Methods and compositions containing a phorbol ester or derivative of a phorbol ester are provided for prevention and treatment of sudden acute respiratory syndrome (SARS) coronavirus infection, including SARS-CoV-2 infection and related COVID-19 disease. Also provided are methods and compositions for preventing and treating acute inflammatory conditions and related pathogenic injuries, including Acute Respiratory Distress Syndrome (ARDS) and cytokine storm syndrome (CSS) seen in severe SARS-CoV-2/COVID-l 9 cases.
Inventors:
CHANG RICHARD (US)
CHANG BEN (US)
CHANG BEN (US)
Application Number:
PCT/US2021/034494
Publication Date:
December 30, 2021
Filing Date:
May 27, 2021
Export Citation:
Assignee:
PHOR MED INC (US)
CHANG RICHARD L (US)
CHANG BEN Y (US)
CHANG RICHARD L (US)
CHANG BEN Y (US)
International Classes:
A61K31/015; A61K31/047; A61K31/122; C07C13/24; C07C49/503; C07C49/513
Domestic Patent References:
| WO2019108456A1 | 2019-06-06 |
Foreign References:
| US20140364492A1 | 2014-12-11 |
Other References:
U LELI, G HAUSER , M FROIMOWITZ: "Requirements for the Activation of Protein Kinase C: Comparison of the Molecular Geometries of Phorbol and Diacylglycerol", MOLECULAR PHARMACOLOGY, vol. 37, no. 2, February 1990 (1990-02-01), pages 286 - 295, XP009541795
Attorney, Agent or Firm:
KING, Jeffrey, J. (US)
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