COMPOSITIONS AND METHODS FOR TREATING AND DETECTING CANCER

Title:

COMPOSITIONS AND METHODS FOR TREATING AND DETECTING CANCER

Document Type and Number:

WIPO Patent Application WO/2024/049829

Kind Code:

A3

Abstract:

A pharmaceutical composition comprising a compound a binding pocket adjacent the wedge domain of an intracellular portion or fragment of the receptor protein tyrosine phosphatase (RPTP) IIb cell adhesion molecules (e.g., PTPμ) and that is capable of inhibiting RPTP mediated adhesion of cells and/or cancer cell growth and/or sphere formation.

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Inventors:

BRADY-KALNAY SUSANN (US)
MOLYNEAUX KATHLEEN (US)
LAGGNER CHRISTIAN (US)

Application Number:

PCT/US2023/031406

Publication Date:

April 11, 2024

Filing Date:

August 29, 2023

Export Citation:

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Assignee:

UNIV CASE WESTERN RESERVE (US)

International Classes:

A61K31/427; A61K31/4245; A61P35/00; C07D277/38; C07D413/14; C07D417/12

Attorney, Agent or Firm:

SUTKUS, Richard, A. (US)

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