Title:
COMPOSITIONS AND METHODS FOR TREATING HYPERPROLIFERATIVE DISORDERS
Document Type and Number:
WIPO Patent Application WO2006050270
Kind Code:
A3
Abstract:
The invention generally relates to a composition comprising an enriched NK cell population. The invention further relates to a method of treating a solid tumor or a hyperproliferative disorder by administering the enriched NK cell population to a mammalian subject in need thereof.
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Inventors:
CHILDS RICHARD WILLIAM WYATT (US)
IGARASHI TAKEHITO (JP)
WYNBERG JASON BENJAMIN (US)
IGARASHI TAKEHITO (JP)
WYNBERG JASON BENJAMIN (US)
Application Number:
PCT/US2005/039282
Publication Date:
August 10, 2006
Filing Date:
October 31, 2005
Export Citation:
Assignee:
US GOV HEALTH & HUMAN SERV (US)
CHILDS RICHARD WILLIAM WYATT (US)
IGARASHI TAKEHITO (JP)
WYNBERG JASON BENJAMIN (US)
CHILDS RICHARD WILLIAM WYATT (US)
IGARASHI TAKEHITO (JP)
WYNBERG JASON BENJAMIN (US)
International Classes:
A61K35/12; C12N5/0783
Domestic Patent References:
| WO1998048630A1 | 1998-11-05 | |||
| WO2005003172A2 | 2005-01-13 | |||
| WO2006003179A2 | 2006-01-12 |
Other References:
IGARASHI TAKEHITO ET AL: "Enhanced cytotoxicity of allogeneic NK cells with killer immunoglobulin-like receptor ligand incompatibility against melanoma and renal cell carcinoma cells", BLOOD, vol. 104, no. 1, 1 July 2004 (2004-07-01), pages 170 - 177, XP002382433, ISSN: 0006-4971
VAN RHEE FRITS ET AL: "KIR-LIGAND mismatched natural killer cells effectively kill primary myeloma and myeloma cell lines.", BLOOD, vol. 104, no. 11, Part 1, November 2004 (2004-11-01), & 46TH ANNUAL MEETING OF THE AMERICAN-SOCIETY-OF-HEMATOLOGY; SAN DIEGO, CA, USA; DECEMBER 04 -07, 2004, pages 672A - 673A, XP002382434, ISSN: 0006-4971
LEUNG WING ET AL: "Determinants of antileukemia effects of allogeneic NK cells.", JOURNAL OF IMMUNOLOGY, vol. 172, no. 1, 1 January 2004 (2004-01-01), pages 644 - 650, XP002382435, ISSN: 0022-1767
KOH C Y ET AL: "NK inhibitory-receptor blockade for purging of leukemia: effects on hematopoietic reconstitution", BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, KLUGE CARDEN JENNINGS PUBLISHING, CHARLOTTESVILLE, VA, US, vol. 8, no. 1, 2002, pages 17 - 25, XP002308879, ISSN: 1083-8791
RUGGERI LOREDANA ET AL: "Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation", BLOOD, vol. 94, no. 1, 1 July 1999 (1999-07-01), pages 333 - 339, XP002382436, ISSN: 0006-4971
RABINOWICH H ET AL: "INCREASED PROLIFERATION, LYTIC ACTIVITY, AND PURITY OF HUMAN NATURAL KILLER CELLS COCULTURED WITH MITOGEN-ACTIVATED FEEDER CELLS", CELLULAR IMMUNOLOGY, ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 135, no. 2, 1991, pages 454 - 470, XP001120159, ISSN: 0008-8749
RUGGERI LOREDANA ET AL: "Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants", SCIENCE (WASHINGTON D C), vol. 295, no. 5562, 15 March 2002 (2002-03-15), pages 2097 - 2100, XP002382437, ISSN: 0036-8075
ZAMBELLO R ET AL: "Expression and function of KIR and natural cytotoxicity receptors in NK-type lymphoproliferative diseases of granular lymphocytes", BLOOD, W.B.SAUNDERS COMPANY, ORLANDO, FL, US, vol. 102, no. 5, 1 September 2003 (2003-09-01), pages 1797 - 1805, XP002340119, ISSN: 0006-4971
GIEBEL SEBASTIAN ET AL: "Survival advantage with KIR ligand incompatibility in hematopoietic stem cell transplantation from unrelated donors.", BLOOD, vol. 102, no. 3, 1 August 2003 (2003-08-01), pages 814 - 819, XP002382438, ISSN: 0006-4971
MALMBERG K-J ET AL: "KIR-ligand mismatch in allogeneic hematopoietic stem cell transplantation", MOLECULAR IMMUNOLOGY, ELMSFORD, NY, US, vol. 42, no. 4, February 2005 (2005-02-01), pages 531 - 534, XP004686649, ISSN: 0161-5890
FARAG S S ET AL: "Natural killer cell receptors: New biology and insights into the graft-versus-leukemia effect", BLOOD, W.B.SAUNDERS COMPANY, ORLANDO, FL, US, vol. 100, no. 6, 15 September 2002 (2002-09-15), pages 1935 - 1947, XP002308880, ISSN: 0006-4971
MORETTA A ET AL: "Receptors for HLA class-I molecules in human natural killer cells", ANNUAL REVIEW OF IMMUNOLOGY, ANNUAL REVIEWS INC, US, vol. 14, 1996, pages 619 - 648, XP002308882, ISSN: 0732-0582
VAN RHEE FRITS ET AL: "KIR-LIGAND mismatched natural killer cells effectively kill primary myeloma and myeloma cell lines.", BLOOD, vol. 104, no. 11, Part 1, November 2004 (2004-11-01), & 46TH ANNUAL MEETING OF THE AMERICAN-SOCIETY-OF-HEMATOLOGY; SAN DIEGO, CA, USA; DECEMBER 04 -07, 2004, pages 672A - 673A, XP002382434, ISSN: 0006-4971
LEUNG WING ET AL: "Determinants of antileukemia effects of allogeneic NK cells.", JOURNAL OF IMMUNOLOGY, vol. 172, no. 1, 1 January 2004 (2004-01-01), pages 644 - 650, XP002382435, ISSN: 0022-1767
KOH C Y ET AL: "NK inhibitory-receptor blockade for purging of leukemia: effects on hematopoietic reconstitution", BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, KLUGE CARDEN JENNINGS PUBLISHING, CHARLOTTESVILLE, VA, US, vol. 8, no. 1, 2002, pages 17 - 25, XP002308879, ISSN: 1083-8791
RUGGERI LOREDANA ET AL: "Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation", BLOOD, vol. 94, no. 1, 1 July 1999 (1999-07-01), pages 333 - 339, XP002382436, ISSN: 0006-4971
RABINOWICH H ET AL: "INCREASED PROLIFERATION, LYTIC ACTIVITY, AND PURITY OF HUMAN NATURAL KILLER CELLS COCULTURED WITH MITOGEN-ACTIVATED FEEDER CELLS", CELLULAR IMMUNOLOGY, ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 135, no. 2, 1991, pages 454 - 470, XP001120159, ISSN: 0008-8749
RUGGERI LOREDANA ET AL: "Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants", SCIENCE (WASHINGTON D C), vol. 295, no. 5562, 15 March 2002 (2002-03-15), pages 2097 - 2100, XP002382437, ISSN: 0036-8075
ZAMBELLO R ET AL: "Expression and function of KIR and natural cytotoxicity receptors in NK-type lymphoproliferative diseases of granular lymphocytes", BLOOD, W.B.SAUNDERS COMPANY, ORLANDO, FL, US, vol. 102, no. 5, 1 September 2003 (2003-09-01), pages 1797 - 1805, XP002340119, ISSN: 0006-4971
GIEBEL SEBASTIAN ET AL: "Survival advantage with KIR ligand incompatibility in hematopoietic stem cell transplantation from unrelated donors.", BLOOD, vol. 102, no. 3, 1 August 2003 (2003-08-01), pages 814 - 819, XP002382438, ISSN: 0006-4971
MALMBERG K-J ET AL: "KIR-ligand mismatch in allogeneic hematopoietic stem cell transplantation", MOLECULAR IMMUNOLOGY, ELMSFORD, NY, US, vol. 42, no. 4, February 2005 (2005-02-01), pages 531 - 534, XP004686649, ISSN: 0161-5890
FARAG S S ET AL: "Natural killer cell receptors: New biology and insights into the graft-versus-leukemia effect", BLOOD, W.B.SAUNDERS COMPANY, ORLANDO, FL, US, vol. 100, no. 6, 15 September 2002 (2002-09-15), pages 1935 - 1947, XP002308880, ISSN: 0006-4971
MORETTA A ET AL: "Receptors for HLA class-I molecules in human natural killer cells", ANNUAL REVIEW OF IMMUNOLOGY, ANNUAL REVIEWS INC, US, vol. 14, 1996, pages 619 - 648, XP002308882, ISSN: 0732-0582
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