Title:
COMPOSITIONS AND METHODS OF TREATING INFLAMMATION
Document Type and Number:
WIPO Patent Application WO/2011/020095
Kind Code:
A3
Abstract:
A method of treating a lymphocyte mediated inflammation in a subject including administering a therapeutically effective amount of a cell delivery composition to the subject, the cell delivery composition of the application including an immunosuppressive cell and a plurality of targeting moieties that bind to endothelial cell adhesion molecules expressed by endothelial cells as a result of a lymphocyte mediated inflammatory response in the subject, the targeting moieties coated on and linked to the immunosuppressive cell and enhancing adherence of the immunosuppressive cell to an endothelial cell at a site of lymphocyte mediated inflammation when administered to the subject systemically, wherein the cell delivery composition, suppresses lymphocyte mediated inflammation in the subject.
Inventors:
DENNIS JAMES E (US)
KEAN THOMAS (US)
KEAN THOMAS (US)
Application Number:
PCT/US2010/045613
Publication Date:
June 16, 2011
Filing Date:
August 16, 2010
Export Citation:
Assignee:
UNIV CASE WESTERN RESERVE
DENNIS JAMES E (US)
KEAN THOMAS (US)
DENNIS JAMES E (US)
KEAN THOMAS (US)
International Classes:
A61K39/395; A61K35/12; A61K35/28; A61P1/16; A61P3/10; A61P29/00; A61K39/00
Foreign References:
| KR20090065478A | 2009-06-22 |
Other References:
GISELLE CHAMBERLAIN ET AL.: "Concise Review: Mesenchymal Stem Cells: Their Phenotype, Differentiation Capacity, Immunological Features, and Potential for Homing.", STEM CELLS, vol. 25, no. 11, 2007, pages 2739 - 2749, XP055018344, DOI: doi:10.1634/stemcells.2007-0197
ANTONIO SORIANO ET AL.: "VCAM-1, but not ICAM-1 or MAdCAM-1, immunoblockade ameliorates DSS-induced colitis in mice.", LABORATORY INVESTIGATION, vol. 80, no. 10, 2000, pages 1541 - 1552, XP009132544
E. SPAETH ET AL.: "Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells.", GENE THERAPY, vol. 15, no. 10, 2008, pages 730 - 738, XP055050680, DOI: doi:10.1038/gt.2008.39
RONALD P. PELLETIER ET AL.: "Importance of endothelial VCAM-1 for inflammatory leukocytic infiltration in vivo.", THE JOURNAL OF IMMUNOLOGY: OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS, vol. 149, no. 7, 1992, pages 2473 - 2481
ANTONIO SORIANO ET AL.: "VCAM-1, but not ICAM-1 or MAdCAM-1, immunoblockade ameliorates DSS-induced colitis in mice.", LABORATORY INVESTIGATION, vol. 80, no. 10, 2000, pages 1541 - 1552, XP009132544
E. SPAETH ET AL.: "Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells.", GENE THERAPY, vol. 15, no. 10, 2008, pages 730 - 738, XP055050680, DOI: doi:10.1038/gt.2008.39
RONALD P. PELLETIER ET AL.: "Importance of endothelial VCAM-1 for inflammatory leukocytic infiltration in vivo.", THE JOURNAL OF IMMUNOLOGY: OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS, vol. 149, no. 7, 1992, pages 2473 - 2481
Attorney, Agent or Firm:
SUTKUS, Richard, A. (Sundheim Covell & Tummino LLP,1300 East Ninth Street Suite 170, Cleveland OH, US)
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