Title:
COMPOSITIONS AND METHODS FOR TREATING OBESITY
Document Type and Number:
WIPO Patent Application WO/2022/221291
Kind Code:
A3
Abstract:
The disclosure provides methods of treating obesity, reducing weight, or preventing weight gain using a combination therapy of GDF15 polypeptide and a myostatin inhibitor (e.g., a myostatin propeptide).
Inventors:
HAMMERS DAVID (US)
SWEENEY HUGH (US)
SWEENEY HUGH (US)
Application Number:
PCT/US2022/024440
Publication Date:
November 17, 2022
Filing Date:
April 12, 2022
Export Citation:
Assignee:
UNIV FLORIDA (US)
International Classes:
C07K14/475; A61K38/00; A61P3/04; C07K14/495; C12N15/62; C12N15/85
Domestic Patent References:
| WO2017201527A2 | 2017-11-23 | |||
| WO2020084496A1 | 2020-04-30 |
Foreign References:
| US20190345251A1 | 2019-11-14 |
Other References:
GUO WEN, WONG SIU, BHASIN SHALENDER: "AAV-Mediated Administration of Myostatin Pro-Peptide Mutant in Adult Ldlr Null Mice Reduces Diet-Induced Hepatosteatosis and Arteriosclerosis", PLOS ONE, vol. 8, no. 8, 1 August 2013 (2013-08-01), XP093008142, DOI: 10.1371/journal.pone.0071017
Attorney, Agent or Firm:
CHIMALAKONDA, Gitanjali et al. (US)
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