Title:
COMPOSITIONS AND METHODS FOR TREATING PANCREATIC CANCER
Document Type and Number:
WIPO Patent Application WO/2024/010841
Kind Code:
A3
Abstract:
In the various aspects and embodiments, the present disclosure provides compositions and methods for treating pancreatic cancer (e.g., pancreatic ductal adenocarcinoma, or PDAC). In accordance with aspects of the disclosure, the composition comprises an aptamer that targets accumulation of the composition to pancreatic cancer cells, and an antisense oligonucleotide that inhibits the expression of an mRNA associated with key signaling pathways that promote proliferation or survival in pancreatic cancer cells, such as the KRAS -RAF -MEK-ERK signaling pathway or RTK-RAS-ERK cascade. Exemplary antisense oligonucleotides described herein target KRAS, including mutant KRAS. Exemplary antisense oligonucleotides described herein target SOS1 and/or SOS2 transcripts.
Inventors:
CHEN LISHAN (US)
JIN BOHAN (US)
CHEN YUCHING (US)
TRUONG ROSALINE (US)
JIN BOHAN (US)
CHEN YUCHING (US)
TRUONG ROSALINE (US)
Application Number:
PCT/US2023/026980
Publication Date:
April 11, 2024
Filing Date:
July 06, 2023
Export Citation:
Assignee:
MOLECULAR AXIOM LLC (US)
International Classes:
C12N15/115; A61K47/54; A61P35/00; C12N15/113; A61K31/7088; A61K31/713; C12Q1/68
Attorney, Agent or Firm:
HAYMAN, Mark, L. et al. (US)
Download PDF: