Title:
COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING VASOMOTOR SYMPTOMS
Document Type and Number:
WIPO Patent Application WO/2019/124366
Kind Code:
A1
Abstract:
The present disclosure is directed to compositions comprising as an active ingredient, a lower dose of 4-({(1-cyclopropylisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl] amino}sulfonyl)benzoic acid or a pharmaceutically acceptable salt thereof for treating or preventing vasomotor symptoms in a subject, and methods which comprises administering the said compound or the pharmaceutically acceptable salt thereof at a lower dose, respectively.
Inventors:
PALUMBO JOSEPH M (US)
Application Number:
PCT/JP2018/046544
Publication Date:
June 27, 2019
Filing Date:
December 18, 2018
Export Citation:
Assignee:
MITSUBISHI TANABE PHARMA CORP (JP)
International Classes:
A61K31/47; A61P15/12
Domestic Patent References:
| WO2017217351A1 | 2017-12-21 | |||
| WO2014042238A1 | 2014-03-20 |
Foreign References:
| US8987445B2 | 2015-03-24 | |||
| US8987445B2 | 2015-03-24 | |||
| US9096527B2 | 2015-08-04 |
Other References:
M. C. ALMEIDA ET AL: "Pharmacological Blockade of the Cold Receptor TRPM8 Attenuates Autonomic and Behavioral Cold Defenses and Decreases Deep Body Temperature", THE JOURNAL OF NEUROSCIENCE, vol. 32, no. 6, 8 February 2012 (2012-02-08), US, pages 2086 - 2099, XP055565873, ISSN: 0270-6474, DOI: 10.1523/JNEUROSCI.5606-11.2012
MCKEMY D D ET AL: "Identification of a cold receptor reveals a general role for TRP channels in thermosensation", NATURE, MACMILLAN JOURNALS LTD, LONDON, vol. 416, 1 January 2002 (2002-01-01), pages 52 - 58, XP002250383, ISSN: 0028-0836, DOI: 10.1038/NATURE719
R. E. WILLIAMS ET AL.: "Frequency and severity of vasomotor symptoms among peri- and postmenopausal women in the United States", CLIMACTERIC, vol. 11, 2008, pages 32 - 43
LAURA J. HANISCH ET AL.: "Increases in core body temperature precede hot flashes in a prostate cancer patient", PSYCHO-ONCOLOGY, vol. 18, 2009, pages 564 - 567
KAREN ELKIND-HIRSCH: "Cooling off hot flashes: uncoupling of the circadian pattern of core body temperature and hot flash frequency in breast cancer survivors", MENOPAUSE: THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, vol. 11, no. 4, 2004, pages 369 - 371
HADINE JOFFE ET AL.: "A Gonadotropin-Releasing Hormone Agonist Model Demonstrates That Nocturnal Hot Flashes Interrupt Objective Sleep", SLEEP, vol. 36, no. 12, 2013, pages 1977 - 1985
NASEEM A. AZIZ: "Evaluation of Core and Surface Body Temperatures, Prevalence, Onset, Duration and Severity of Hot Flashes in Men after Bilateral Or-chidectomy for Prostate Cancer", INT. BRAZ. J. UROL., vol. 34, 2008, pages 15 - 22
"Hot flushes in a male population aged 55, 65, and 75 years, living in the community of Linkoeping, Sweden", MENOPAUSE, vol. 10, no. 1, 2003, pages 81 - 87
MCKEMY ET AL.: "Identification of a cold receptor reveals a general role for TRP channels in thermosensation", NATURE, vol. 416, no. 6876, 2002, pages 52 - 58, XP002250383, DOI: doi:10.1038/nature719
ABE ET AL.: "Ca2±-dependent PKC activation mediates menthol-induced desensitization of transient receptor potential M8", NEUROSCIENCE LETTERS, vol. 397, no. 1-2, 2006, pages 140 - 144, XP025024002, DOI: doi:10.1016/j.neulet.2005.12.005
PREMKUMAR ET AL.: "Downregulation of Transient Receptor Potential Melastatin 8 by Protein Kinase C-Mediated Dephosphorylation", THE JOURNAL OF NEUROSCIENCE, vol. 25, no. 49, 2005, pages 11322 - 11329
GAGGE'S, TWO-NODE MODEL, ASHRAE TRANSACTIONS, vol. 77, 1971, pages 247 - 62
"Metabolic heat production model with circadian rhythm", J. PHARMACOL. EXP. THER., vol. 317, 2006, pages 209 - 19
TEMPERATURE, vol. 1, 2014, pages 142 - 9
J STEROID BIOCHEM MOL BIOL., vol. 142, July 2014 (2014-07-01), pages 115 - 120
MCKEMY D D ET AL: "Identification of a cold receptor reveals a general role for TRP channels in thermosensation", NATURE, MACMILLAN JOURNALS LTD, LONDON, vol. 416, 1 January 2002 (2002-01-01), pages 52 - 58, XP002250383, ISSN: 0028-0836, DOI: 10.1038/NATURE719
R. E. WILLIAMS ET AL.: "Frequency and severity of vasomotor symptoms among peri- and postmenopausal women in the United States", CLIMACTERIC, vol. 11, 2008, pages 32 - 43
LAURA J. HANISCH ET AL.: "Increases in core body temperature precede hot flashes in a prostate cancer patient", PSYCHO-ONCOLOGY, vol. 18, 2009, pages 564 - 567
KAREN ELKIND-HIRSCH: "Cooling off hot flashes: uncoupling of the circadian pattern of core body temperature and hot flash frequency in breast cancer survivors", MENOPAUSE: THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, vol. 11, no. 4, 2004, pages 369 - 371
HADINE JOFFE ET AL.: "A Gonadotropin-Releasing Hormone Agonist Model Demonstrates That Nocturnal Hot Flashes Interrupt Objective Sleep", SLEEP, vol. 36, no. 12, 2013, pages 1977 - 1985
NASEEM A. AZIZ: "Evaluation of Core and Surface Body Temperatures, Prevalence, Onset, Duration and Severity of Hot Flashes in Men after Bilateral Or-chidectomy for Prostate Cancer", INT. BRAZ. J. UROL., vol. 34, 2008, pages 15 - 22
"Hot flushes in a male population aged 55, 65, and 75 years, living in the community of Linkoeping, Sweden", MENOPAUSE, vol. 10, no. 1, 2003, pages 81 - 87
MCKEMY ET AL.: "Identification of a cold receptor reveals a general role for TRP channels in thermosensation", NATURE, vol. 416, no. 6876, 2002, pages 52 - 58, XP002250383, DOI: doi:10.1038/nature719
ABE ET AL.: "Ca2±-dependent PKC activation mediates menthol-induced desensitization of transient receptor potential M8", NEUROSCIENCE LETTERS, vol. 397, no. 1-2, 2006, pages 140 - 144, XP025024002, DOI: doi:10.1016/j.neulet.2005.12.005
PREMKUMAR ET AL.: "Downregulation of Transient Receptor Potential Melastatin 8 by Protein Kinase C-Mediated Dephosphorylation", THE JOURNAL OF NEUROSCIENCE, vol. 25, no. 49, 2005, pages 11322 - 11329
GAGGE'S, TWO-NODE MODEL, ASHRAE TRANSACTIONS, vol. 77, 1971, pages 247 - 62
"Metabolic heat production model with circadian rhythm", J. PHARMACOL. EXP. THER., vol. 317, 2006, pages 209 - 19
TEMPERATURE, vol. 1, 2014, pages 142 - 9
J STEROID BIOCHEM MOL BIOL., vol. 142, July 2014 (2014-07-01), pages 115 - 120
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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