Title:
COMPOSITIONS AND METHODS FOR THE TREATMENT OF ACTINOMYCETIA INFECTIONS
Document Type and Number:
WIPO Patent Application WO/2023/196951
Kind Code:
A3
Abstract:
The present disclosure features compositions and methods for the treatment of actinomycetia (e.g., corynebacteriales) infections, e.g., caused by mycobacterial cells, residing within a host cell (e.g., a mammalian cell, e.g., immune cell, e.g., macrophage or dendritic cell). The compositions and methods include delivering a mixture of lytic enzymes to specifically target the cell envelope of a group of related bacterial species in the intracellular compartment (endosome, phagosome, lysosome, or cytosol) in which above mentioned orders of bacteria infect, grow, hide, and go quiescent.
Inventors:
HOLDER JASON (US)
BARTLETT HELEN (US)
BARRIOS SONIA (US)
DAWSON CLINTON (US)
SOLOMON KEITH (US)
GLICKMAN CODY (US)
BARTLETT HELEN (US)
BARRIOS SONIA (US)
DAWSON CLINTON (US)
SOLOMON KEITH (US)
GLICKMAN CODY (US)
Application Number:
PCT/US2023/065497
Publication Date:
November 09, 2023
Filing Date:
April 07, 2023
Export Citation:
Assignee:
ENDOLYTIX TECH INC (US)
International Classes:
A61K38/51; A61K38/43; A61K38/47; A61K47/69; A61P31/04; C07K14/195
Domestic Patent References:
| WO2021178968A1 | 2021-09-10 |
Foreign References:
| US20150344859A1 | 2015-12-03 |
Other References:
DATABASE UNIPROTKB ANONYMOUS : "A0A5J6TK43 ยท A0A5J6TK43_9CAUD", XP093108587, retrieved from UNIPROT
Attorney, Agent or Firm:
BELLIVEAU, Michael, J. et al. (US)
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