Title:
COMPOSITIONS AND METHODS FOR TREATMENT OF CYTOMEGALOVIRUS
Document Type and Number:
WIPO Patent Application WO/2013/068847
Kind Code:
A3
Abstract:
The present disclosure provides compositions and methods useful for treating HCMV infection. As described herein, the compositions and methods are based on development of immunogenic compositions that include virus-like particles (VLPs) which comprise one or more Moloney Murine leukemia virus (MMLV) core proteins and include one or more HCMV epitopes, such as, for example, from HCMV envelope glycoproteins gB and/or gH and/or tegument protein pp65. Among other things, the present invention encompasses the recognition that a combination of antigens (e.g., envelope glycoproteins and structural proteins) can lead to beneficial immune responses, for example that include both a humoral response (e.g., production of neutralizing antibodies) and a cellular response (e.g., T-cell activation).
Inventors:
ANDERSON DAVID E (US)
FLUCKIGER ANNE-CATHERINE (FR)
FLUCKIGER ANNE-CATHERINE (FR)
Application Number:
PCT/IB2012/002854
Publication Date:
October 30, 2014
Filing Date:
November 09, 2012
Export Citation:
Assignee:
VARIATION BIOTECHNOLOGIES INC (CA)
International Classes:
C12N15/63; A61K39/245; A61K39/295; A61P31/22; A61P37/04; C07K14/045; C07K14/145; C07K14/15; C07K19/00; C12N7/01; C12N7/04; C12N15/38; C12N15/48; C12N15/62; C12N15/86
Domestic Patent References:
| WO2010128338A2 | 2010-11-11 |
Foreign References:
| US20090123494A1 | 2009-05-14 |
Other References:
See also references of EP 2776567A4
Attorney, Agent or Firm:
NAUMAN, David et al. (1200 Waterfront Centre200 Burrard St., P.O. Box, Vancouver British Columbia V7X 1T2, CA)
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