Title:
COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION
Document Type and Number:
WIPO Patent Application WO2005020897
Kind Code:
A3
Abstract:
Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.
Inventors:
NATARAJAN SATEESH K (US)
MORENO OFIR (US)
GRADDIS THOMAS J (US)
DUNCAN DAVID (US)
LAUS REINER (US)
CHEN FENG (US)
MORENO OFIR (US)
GRADDIS THOMAS J (US)
DUNCAN DAVID (US)
LAUS REINER (US)
CHEN FENG (US)
Application Number:
PCT/US2004/026931
Publication Date:
August 11, 2005
Filing Date:
August 20, 2004
Export Citation:
Assignee:
DENDREON CORP (US)
NATARAJAN SATEESH K (US)
MORENO OFIR (US)
GRADDIS THOMAS J (US)
DUNCAN DAVID (US)
LAUS REINER (US)
CHEN FENG (US)
NATARAJAN SATEESH K (US)
MORENO OFIR (US)
GRADDIS THOMAS J (US)
DUNCAN DAVID (US)
LAUS REINER (US)
CHEN FENG (US)
International Classes:
A61K31/498; A61K31/517; A61K45/06; C07C311/20; C07C311/37; C07C323/40; C07C323/44; C07C333/06; C07D207/06; C07D207/09; C07D207/325; C07D209/08; C07D209/14; C07D209/20; C07D209/48; C07D213/40; C07D215/04; C07D215/08; C07D215/46; C07D217/06; C07D231/12; C07D231/14; C07D231/56; C07D235/18; C07D235/26; C07D239/42; C07D241/18; C07D241/44; C07D251/54; C07D263/34; C07D263/57; C07D279/12; C07D295/096; C07D295/135; C07D295/26; C07D307/52; C07D317/66; C07D333/34; C07D401/04; C07D405/12; C07D413/04; C07D413/12; C07D417/04; C07D471/04; C07D487/04; C07D493/08; C07D495/04; C07D513/04; G01N33/68; C07D207/32; C07D263/56; (IPC1-7): C07C303/00; C07C321/00; C07C69/95; C07C69/76; C07C35/08; C07C35/12; C07D345/00
Other References:
DATABASE CAPLUS [online] BARDSHEV ET AL: "Synthesis and Pesticide Activity of Some Amino Derivatives of Terpenoids.", XP002988516, accession no. STN Database accession no. (1985:24839)
DATABASE CAPLUS [online] KOSOLOV ET AL: "Reduction amination of 1-menthol by aliphatic nitrites.", XP002988517, accession no. STN Database accession no. (1981:620155)
DATABASE CAPLUS [online] VOISIN ET AL: "Stereochemical Studies. X. Solvent Effects on the Optical Activity of Conformers and on Conformational Equilibrium.", XP002988518, accession no. STN Database accession no. (1971:510429)
DATABASE CAPLUS [online] KOSOLOV ET AL: "Reduction amination of 1-menthol by aliphatic nitrites.", XP002988517, accession no. STN Database accession no. (1981:620155)
DATABASE CAPLUS [online] VOISIN ET AL: "Stereochemical Studies. X. Solvent Effects on the Optical Activity of Conformers and on Conformational Equilibrium.", XP002988518, accession no. STN Database accession no. (1971:510429)
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