Title:
COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASE BY MANIPULATION OF SERINE METABOLISM
Document Type and Number:
WIPO Patent Application WO/2021/142132
Kind Code:
A1
Abstract:
The present disclosure relates, in various embodiments, to methods of treating various NADH-mediated diseases and disorders in a subject, such as disorders characterized by excess NADH, for example, by inhibiting serine catabolism in the subject.
Inventors:
RABINOWITZ JOSHUA D (US)
YANG LIFENG (US)
YANG LIFENG (US)
Application Number:
PCT/US2021/012516
Publication Date:
July 15, 2021
Filing Date:
January 07, 2021
Export Citation:
Assignee:
UNIV PRINCETON (US)
International Classes:
A61K31/155; A61K31/35
Domestic Patent References:
| WO2001062726A2 | 2001-08-30 | |||
| WO2015049149A1 | 2015-04-09 |
Foreign References:
| US10077273B2 | 2018-09-18 | |||
| US20170064618W | 2017-12-05 | |||
| US20160045086W | 2016-08-02 | |||
| JP2017004194W | 2017-02-06 | |||
| US20160066666W | 2016-12-14 | |||
| US20180117010A1 | 2018-05-03 | |||
| US20180072751A1 | 2018-03-15 | |||
| US4235871A | 1980-11-25 | |||
| US4501728A | 1985-02-26 | |||
| US4837028A | 1989-06-06 | |||
| US4737323A | 1988-04-12 |
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