Title:
COMPOSITIONS AND METHODS FOR TREATMENT OF INFLAMMATORY DISORDERS
Document Type and Number:
WIPO Patent Application WO/2021/236564
Kind Code:
A3
Abstract:
The present disclosure provides, inter alia, compositions, cell populations and pharmaceutical compositions and methods useful for the treatment of inflammatory diseases or disorders. In some embodiments, the compositions, cell populations and pharmaceutical compositions and methods comprise a population of CD44+ cells modified ex vivo via treatment with a CD44 ligand for a period of time sufficient to prime the cells to produce elevated levels of one or more anti-inflammatory or immunomodulatory molecules relative to a native population of CD44+ cells. In some embodiments, the compositions, cell populations and pharmaceutical compositions and methods comprise a population of CD44+ cells modified ex vivo via a treatment that is effective to target cells to sites of inflammation.
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Inventors:
SACKSTEIN ROBERT (US)
Application Number:
PCT/US2021/032859
Publication Date:
December 30, 2021
Filing Date:
May 18, 2021
Export Citation:
Assignee:
SACKSTEIN ROBERT (US)
International Classes:
C07K14/705; A61K35/28; C07K14/54; C12N5/0775
Domestic Patent References:
| WO2019245904A1 | 2019-12-26 | |||
| WO2004082610A2 | 2004-09-30 | |||
| WO2019099927A1 | 2019-05-23 |
Foreign References:
| US20200016199A1 | 2020-01-16 |
Other References:
GARCIA-BERNAL ET AL.: "Exofucosylation of Adipose Mesenchymal Stromal Cells Alters Their Secretome Profile", FRONT CELL DEV BIOL., vol. 8, no. 584074, 26 October 2020 (2020-10-26), pages 58074, XP055891436
Attorney, Agent or Firm:
FITZPATRICK, Ethan (US)
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