Title:
COMPOSITIONS AND METHODS FOR TREATMENT OF NEUROINFLAMMATORY DISEASES
Document Type and Number:
WIPO Patent Application WO/2024/073589
Kind Code:
A8
Abstract:
The present disclosure provides single- or double-stranded interfering RNA molecules (e.g., siRNA) that target a membrane-spanning 4-domains AGA (MS4A6A) gene. The interfering RNA molecules may contain specific patterns of nucleoside modifications and internucleoside linkage modifications, as pharmaceutical compositions including the same. The siRNA molecules may be branched siRNA molecules, such as di-branched, tri-branched, or tetra-branched siRNA molecules. The disclosed siRNA molecules may further feature a 5' phosphorus stabilizing moiety and/or a hydrophobic moiety. Additionally, the disclosure provides methods for delivering the siRNA molecule of the disclosure to the central nervous system of a subject, such as a subject identified as having a neuroinflammatory disease (e.g., Alzheimer's disease).
Inventors:
GALLANT-BEHM CORRIE (US)
KOKULAPLAN WIMALANATHAN (US)
ANDREONE BENJAMIN (US)
HASSLER MATTHEW (US)
CURTIS DANIEL (US)
DA CRUZ GODINHO BRUNO (US)
KOKULAPLAN WIMALANATHAN (US)
ANDREONE BENJAMIN (US)
HASSLER MATTHEW (US)
CURTIS DANIEL (US)
DA CRUZ GODINHO BRUNO (US)
Application Number:
PCT/US2023/075406
Publication Date:
May 10, 2024
Filing Date:
September 28, 2023
Export Citation:
Assignee:
ATALANTA THERAPEUTICS INC (US)
Attorney, Agent or Firm:
QUARTARARO, Justin, S. et al. (US)
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