Title:
COMPOSITIONS AND METHODS FOR THE TREATMENT OF PATHOLOGICAL PAIN AND ITCH
Document Type and Number:
WIPO Patent Application WO/2021/041324
Kind Code:
A3
Abstract:
The present disclosure provides, in part, composition and methods for the treatment of pathological pain and itch.
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Inventors:
LIEDTKE WOLFGANG (US)
Application Number:
PCT/US2020/047655
Publication Date:
April 08, 2021
Filing Date:
August 24, 2020
Export Citation:
Assignee:
UNIV DUKE (US)
International Classes:
C07K14/47; A61P25/00; C12N15/09; C12N15/85; C12N15/86
Domestic Patent References:
| WO2015168666A2 | 2015-11-05 | |||
| WO2018154337A1 | 2018-08-30 |
Foreign References:
| US20190203188A1 | 2019-07-04 | |||
| US20140093476A1 | 2014-04-03 | |||
| US6783982B1 | 2004-08-31 |
Other References:
KOUTRAS, C ET AL.: "Identification of Novel NPRAP/delta-Catenin-Interacting Proteins and the Direct Association of NPRAP with Dynamin 2", PLOS ONE, vol. 6, no. 10, 14 October 2011 (2011-10-14), pages e25379, XP055811326, DOI: 10.1371/joumal.pone.0025379
JUN, G ET AL.: "Delta-Catenin Is Genetically and Biologically Associated with Cortical Cataract and Future Alzheimer-Related Structural and Functional Brain Changes", PLOS ONE, vol. 7, no. 9, 11 September 2012 (2012-09-11), pages e43728, XP055811331, DOI: 10.1371/journal.pone.0043728
ANONYMOUS: "Invitrogen™ pcDNA™3.1/His A, B, & C Mammalian Expression Vectors", THERMOFISHER, 2 March 2012 (2012-03-02), XP055811340, Retrieved from the Internet
HODGES, BL ET AL.: "Long-term Transgene Expression from Plasmid DNA Gene Therapy Vectors Is Negatively Affected by CpG Dinucleotides", MOLECULAR THERAPY, vol. 10, no. 2, August 2004 (2004-08-01), pages 269 - 278, XP004660564, DOI: 10.1016/j.ymthe.2004.04.018
ZHANG, X ET AL.: "Palmitoylation of delta-catenin promotes kinesin-mediated membrane trafficking of Nav1.6 in sensory neurons to promote neuropathic pain", SCIENCE SIGNALING, vol. 11, 27 March 2018 (2018-03-27), pages eaar4394, XP055811332, DOI: 10.1126/scisignal.aar4394
JUN, G ET AL.: "Delta-Catenin Is Genetically and Biologically Associated with Cortical Cataract and Future Alzheimer-Related Structural and Functional Brain Changes", PLOS ONE, vol. 7, no. 9, 11 September 2012 (2012-09-11), pages e43728, XP055811331, DOI: 10.1371/journal.pone.0043728
ANONYMOUS: "Invitrogen™ pcDNA™3.1/His A, B, & C Mammalian Expression Vectors", THERMOFISHER, 2 March 2012 (2012-03-02), XP055811340, Retrieved from the Internet
HODGES, BL ET AL.: "Long-term Transgene Expression from Plasmid DNA Gene Therapy Vectors Is Negatively Affected by CpG Dinucleotides", MOLECULAR THERAPY, vol. 10, no. 2, August 2004 (2004-08-01), pages 269 - 278, XP004660564, DOI: 10.1016/j.ymthe.2004.04.018
ZHANG, X ET AL.: "Palmitoylation of delta-catenin promotes kinesin-mediated membrane trafficking of Nav1.6 in sensory neurons to promote neuropathic pain", SCIENCE SIGNALING, vol. 11, 27 March 2018 (2018-03-27), pages eaar4394, XP055811332, DOI: 10.1126/scisignal.aar4394
Attorney, Agent or Firm:
MCMULLEN, Michelle, L. (US)
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