Title:
COMPOSITIONS AND METHODS FOR TREATMENT OF POUCHITIS
Document Type and Number:
WIPO Patent Application WO2004071453
Kind Code:
A3
Abstract:
The present invention relates methods of treating pouchitis by administering a pharmaceutical formulation suitable for rectal use, such as an enema or suppository, comprising an antisense oligonucleotide targeted to ICAM-1 to an individual.
Inventors:
WEDEL MARK (US)
MINER PHILIP B (US)
MINER PHILIP B (US)
Application Number:
PCT/US2004/004205
Publication Date:
January 05, 2006
Filing Date:
February 12, 2004
Export Citation:
Assignee:
ISIS PHARMACEUTICALS INC (US)
WEDEL MARK (US)
MINER PHILIP B (US)
WEDEL MARK (US)
MINER PHILIP B (US)
International Classes:
A61K9/00; A61K9/107; A61K9/20; A61K31/7088; A61K31/711; A61K47/26; A61K47/44; (IPC1-7): C07H21/04; A61K48/00; C12N15/00
Other References:
GENETIC ENGINEERING NEWS: "ISISPharmaceuticals Demonstrates Efficacy In Crohn's Disease with It's Antisense Drug", GENETIC ENGINEERING NEWS, vol. 17, no. 5, 1997, pages 1 - 34, XP008055466
MINER JR P. ET AL: "An Enema Formulation of Alicaforsen, an Antisense Inhibitor of Intercellular Adhesion Molecule-1, In the Treatment of Chronic, Unremitting Pouchitis", ALIMENT PHARMACOL. THER., vol. 19, 2004, pages 281 - 286, XP002990394
MINER JR P. ET AL: "An Enema Formulation of Alicaforsen, an Antisense Inhibitor of Intercellular Adhesion Molecule-1, In the Treatment of Chronic, Unremitting Pouchitis", ALIMENT PHARMACOL. THER., vol. 19, 2004, pages 281 - 286, XP002990394
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