Title:
COMPOSITIONS AND METHODS FOR USE IN TARGETING VASCULAR DESTRUCTION
Document Type and Number:
WIPO Patent Application WO2000048606
Kind Code:
A9
Abstract:
Treatment of warm-blooded animals having a tumor or non-malignant hypervascularization, by administering a sufficient amount of a cytotoxic agent formulated into a phosphate prodrug form having substrate specificity for microvessel phosphatases, so that microvessels are destroyed preferentially over other normal tissues, because the less cytotoxic prodrug form is converted to the highly cytotoxic dephosphorylated form.
Inventors:
PERO RONALD W
SHERRIS DAVID
SHERRIS DAVID
Application Number:
PCT/US2000/003996
Publication Date:
October 11, 2001
Filing Date:
February 16, 2000
Export Citation:
Assignee:
OXIGENE INC (US)
International Classes:
A61K31/05; A61K31/135; A61K45/00; A61K31/136; A61K31/38; A61K31/381; A61K31/40; A61K31/404; A61K31/66; A61K31/661; A61K31/6615; A61K31/664; A61K31/665; A61K31/67; A61K31/683; A61P9/00; A61P35/00; C07D209/12; C07D333/56; C12Q1/02; A61K; (IPC1-7): A61K31/661; A61K31/6615; A61K31/664
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