COMPOSITIONS AND METHODS OF USE OF LIGANDS THAT BIND COMPONENTS OF THE BLOOD COAGULATION/CLOTTING PATHWAY FOR THE TREATMENT OF CANCER AND ANGIOGENIC-BASED DISEASE

Title:

COMPOSITIONS AND METHODS OF USE OF LIGANDS THAT BIND COMPONENTS OF THE BLOOD COAGULATION/CLOTTING PATHWAY FOR THE TREATMENT OF CANCER AND ANGIOGENIC-BASED DISEASE

Document Type and Number:

WIPO Patent Application WO/2001/027079

Kind Code:

A3

Abstract:

Compositions and methods effective in inhibiting abnormal or undesirable cell proliferation, particularly endothelial cell proliferation and angiogenesis related to neovascularization and tumor growth are provided. The compositions comprise naturally occurring, or synthetic proteins, peptides, or protein fragments capable of binding to components of the blood coagulation pathway. The compositions may be administered using a pharmaceutically acceptable carrier. The methods involve administering to a human or animal the composition described herein in a dosage sufficient to inhibit cell proliferation, particularly endothelial cell proliferation. The methods are useful for treating diseases and processes mediated by undesired and uncontrolled cell proliferation, such as cancer, particularly by inhibiting angiogenesis. Administration of the composition to a human or animal having prevascularized metastasized tumors is useful for preventing the growth or expansion of such tumors.

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Inventors:

GREEN SHAWN J (US)
PAPATHANASSIU ADONIA E (US)

Application Number:

PCT/US2000/028458

Publication Date:

April 11, 2013

Filing Date:

October 13, 2000

Export Citation:

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Assignee:

ENTREMED INC (US)

International Classes:

A61K38/48; A61K38/00; A61K45/00; A61K38/17; A61K38/39; A61K38/43; A61K38/57; A61P1/00; A61P1/04; A61P7/00; A61P9/00; A61P9/08; A61P15/00; A61P17/00; A61P17/06; A61P19/02; A61P19/08; A61P27/02; A61P31/04; A61P35/00; A61P35/02; A61P35/04; A61P43/00; C07K14/81

Domestic Patent References:

WO2000054801A1	2000-09-21
WO2000030628A2	2000-06-02
WO1999060984A2	1999-12-02
WO1999048923A1	1999-09-30

Attorney, Agent or Firm:

GREENE, Jamie, L. et al. (LLP1100 Peachtree Street,Suite 280, Atlanta GA, US)

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