COMPOSITIONS AND METHODS OF USE FOR MODULATORS OF NECTIN 4, SEMAPHORIN 4B, IGSF9, AND KIAA0152 IN TREATING DISEASE

Title:

COMPOSITIONS AND METHODS OF USE FOR MODULATORS OF NECTIN 4, SEMAPHORIN 4B, IGSF9, AND KIAA0152 IN TREATING DISEASE

Document Type and Number:

WIPO Patent Application WO2006014999

Kind Code:

A3

Abstract:

Microarray analysis, confirmed by RT-PCT, demonstrated that mRNA derived from cancerous tissues hybridized specifically and preferentially to human nectin 4, semaphorin 4b, IgSF9, and KIAA0152. Microarray analysis also demonstrated that RNA from malignant bladder, pancreas, and stomach tissue hybridized specifically to human nectin 4, semaphorin 4b, IgSF9, and KIAAO 152, all of which are transmembrane proteins that provide a therapeutic target for treating cancer. Modulators of nectin 4, semaphorin 4b, IgSF9, and KIAAO152 are provided for the diagnosis and treatment of proliferative disorders such as cancer and psoriasis. The invention further provides methods of treating cancer with therapeutic agents directed toward nectin 4, semaphorin 4b, IgSF9, and KIAAO152.

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Inventors:

WONG JUSTIN (US)
HESTIR KEVIN (US)
LEE ERNESTINE (US)

Application Number:

PCT/US2005/026561

Publication Date:

December 21, 2006

Filing Date:

July 27, 2005

Export Citation:

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Assignee:

FIVE PRIME THERAPEUTICS INC (US)
WONG JUSTIN (US)
HESTIR KEVIN (US)
LEE ERNESTINE (US)

International Classes:

C07K14/705; A61K31/7088; A61K38/17; A61K39/395; A61P35/00; C07K16/28; C12N5/10

Domestic Patent References:

WO2003042661A2	2003-05-22
WO2002099040A2	2002-12-12
WO2004073657A2	2004-09-02
WO2004066933A2	2004-08-12
WO2004058817A1	2004-07-15

Other References:

DOUDNEY KIT ET AL: "Cloning and characterization of Igsf9 in mouse and human: A new member of the immunoglobulin superfamily expressed in the developing nervous system", GENOMICS, vol. 79, no. 5, May 2002 (2002-05-01), pages 663 - 670, XP004465137, ISSN: 0888-7543

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