COMPOSITIONS AND METHODS OF USING APOPTOSIS SIGNALING KINASE RELATED KINASE (ASKRK)

Title:

COMPOSITIONS AND METHODS OF USING APOPTOSIS SIGNALING KINASE RELATED KINASE (ASKRK)

Document Type and Number:

WIPO Patent Application WO2005044993

Kind Code:

A3

Abstract:

The invention provides apoptosis signaling kinase related kinase (ASKRK) nucleic acid and polypeptide sequences and methods of using such sequences to identify modulators of ASKRK. Such modulators can be used for the treatment of diabetes or for delaying the onset of diabetes. The invention also provides methods of diagnosing diabetes or pre-diabetes and methods of making a prognosis based on the detection of ASKRK nucleic acids and proteins.

Inventors:

JOHNSON JEFFREY D (US)
ZHOU YUN-PING (US)
MARLEN KIMBERLY (US)

Application Number:

PCT/US2004/036740

Publication Date:

March 09, 2006

Filing Date:

November 03, 2004

Export Citation:

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Assignee:

METABOLEX INC (US)
JOHNSON JEFFREY D (US)
ZHOU YUN-PING (US)
MARLEN KIMBERLY (US)

International Classes:

A61K48/00; C07H21/02; C07K14/47; C07K14/575; C07K14/72; C12N9/12; C12Q1/68; A61K38/00; C12N; (IPC1-7): C12Q1/68; C07H21/04; C12N5/06; C12N9/12; C12P21/02

Domestic Patent References:

WO2001077338A2	2001-10-18
WO2002046384A2	2002-06-13

Other References: