Title:
COMPOSITIONS AND METHODS FOR WT1 SPECIFIC IMMUNOTHERAPY
Document Type and Number:
WIPO Patent Application WO2002028414
Kind Code:
B1
Abstract:
Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.
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Inventors:
GAIGER ALEXANDER (US)
MCNEILL PATRICIA D (US)
SMITHGALL MOLLY (US)
MOULTON GUS (US)
VEDVICK THOMAS S (US)
SLEATH PAUL R (US)
MOSSMAN SALLY (US)
EVANS LAWRENCE (US)
SPIES A GREGORY (US)
BOYDSTON JEREMY (US)
MCNEILL PATRICIA D (US)
SMITHGALL MOLLY (US)
MOULTON GUS (US)
VEDVICK THOMAS S (US)
SLEATH PAUL R (US)
MOSSMAN SALLY (US)
EVANS LAWRENCE (US)
SPIES A GREGORY (US)
BOYDSTON JEREMY (US)
Application Number:
PCT/US2001/031139
Publication Date:
July 18, 2002
Filing Date:
October 03, 2001
Export Citation:
Assignee:
CORIXA CORP (US)
GAIGER ALEXANDER (US)
MCNEILL PATRICIA D (US)
SMITHGALL MOLLY (US)
MOULTON GUS (US)
VEDVICK THOMAS S (US)
SLEATH PAUL R (US)
MOSSMAN SALLY (US)
EVANS LAWRENCE (US)
SPIES A GREGORY (US)
BOYDSTON JEREMY (US)
GAIGER ALEXANDER (US)
MCNEILL PATRICIA D (US)
SMITHGALL MOLLY (US)
MOULTON GUS (US)
VEDVICK THOMAS S (US)
SLEATH PAUL R (US)
MOSSMAN SALLY (US)
EVANS LAWRENCE (US)
SPIES A GREGORY (US)
BOYDSTON JEREMY (US)
International Classes:
G01N33/574; A61K31/7088; A61K35/14; A61K38/00; A61K39/00; A61K39/39; A61K39/395; A61K45/00; A61P35/00; A61P35/02; A61P37/04; C07K14/47; C07K14/82; C07K16/32; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12Q1/68; A61K48/00; (IPC1-7): A61K38/16; A61K38/17; C07H21/02; C07H21/04; C07K14/435; C12N5/10; G01N33/53
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