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Title:
COMPOSITIONS AND RELATED METHODS FOR TREATING AND PREVENTING VIRAL AND RETROVIRAL INFECTIONS
Document Type and Number:
WIPO Patent Application WO/2015/148684
Kind Code:
A3
Abstract:
Disclosed are pharmaceutical compositions and related methods for treating a subject with a viral or retroviral infection. The disclosed compositions and methods comprise and utilize an effective amount of one or more vanadium-containing compounds and an effective amount of one or more sulfonylureas. In certain embodiments, the viral infection is human immunodeficiency virus (HIV) and the compositions and methods improve one or more immunologic cellular parameters, such as viral load, CD4 counts and CD4/CD8 lymphocyte cell ratios in a subject. Also disclosed are methods of improving one or more immunologic cellular parameters that are associated with viral infections such as HIV in a subject, including viral load, CD4 counts and CD4/CD8 lymphocyte cell ratios.

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Inventors:
GUTIERREZ ENRIQUE G (US)
Application Number:
PCT/US2015/022513
Publication Date:
December 03, 2015
Filing Date:
March 25, 2015
Export Citation:
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Assignee:
GUTIERREZ ENRIQUE G (US)
International Classes:
A01N47/34; A61K33/24
Foreign References:
US20020013268A12002-01-31
US5093327A1992-03-03
US20050233946A12005-10-20
US5885980A1999-03-23
Other References:
WONG ET AL.: "Physiologically stable vanadium porphyrins as a new class of anti-HIV agents;", CHEM. COMMUN., no. 28, 2005, pages 3544 - 3546, XP055238888, ISSN: 1359-7345
CUSI ET AL.: "vanadyl Sulfate improves hepatic and muscle insulin sensitivity in Type 2 Diabetes;", J. CLIN. ENDOCRINOLOGY AND METABOLISM ;, vol. 86, no. 3, 2001, pages 1410 - 1417, XP055238889, ISSN: 0021-972x
Attorney, Agent or Firm:
CHALVIRE, Stanley, F. (Barnes-Brown & Pendleton P.C.,Citypoint,230 Third Avenue, 4th Floo, Waltham MA, US)
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