Title:
COMPOSITIONS AND THERAPEUTIC AGENTS FOR MODULATING INFLAMMATORY RESPONSES ON BOTH TUMOR AND IMMUNE CELLS
Document Type and Number:
WIPO Patent Application WO/2023/240291
Kind Code:
A3
Abstract:
The relationship between macrophage polarization and cancer progression depending on tumor location and microenvironment has been elusive. New agents and methods for directing macrophage polarization and modulating the host immune response are needed. Disclose are compositions and methods related to the detection, prognosis and treatment of a cancer related to the expression level of CMTM4. In one aspect, the disclosure provides for siRNAs and small molecules that can inhibit CMTM4 for the treatment of cancer.
Inventors:
CHEN SHU-HSIA (US)
KANG KYEONGAH (US)
PAN PING-YING (US)
KANG KYEONGAH (US)
PAN PING-YING (US)
Application Number:
PCT/US2023/068302
Publication Date:
April 11, 2024
Filing Date:
June 12, 2023
Export Citation:
Assignee:
METHODIST HOSPITAL (US)
International Classes:
C12Q1/6886; A61P35/00; G01N33/53; G01N33/574; G01N33/68
Attorney, Agent or Firm:
LANIER, J., Gibson et al. (US)
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