Title:
COMPOSITIONS FOR TRANSFER OF CARGO TO CELLS
Document Type and Number:
WIPO Patent Application WO/2021/053405
Kind Code:
A3
Abstract:
The invention provides compositions containing cargo molecules attached to elements that improve the function of the cargo molecules in the body of a subject. The compositions are useful for therapeutic and diagnostic purposes.
Inventors:
FOOT GEORGE (GB)
ROSELL ANNA (GB)
BRZOSKO ZUZANNA (GB)
GASSER CATHERINA (GB)
ROSELL ANNA (GB)
BRZOSKO ZUZANNA (GB)
GASSER CATHERINA (GB)
Application Number:
PCT/IB2020/001023
Publication Date:
June 03, 2021
Filing Date:
August 28, 2020
Export Citation:
Assignee:
SIXFOLD BIOSCIENCE LTD (GB)
International Classes:
C12N15/11; A61K31/7088; A61K48/00; B82Y5/00; C12N15/87
Domestic Patent References:
| WO2012125987A2 | 2012-09-20 | |||
| WO2014170898A1 | 2014-10-23 | |||
| WO2019166877A1 | 2019-09-06 |
Foreign References:
| US20160208245A1 | 2016-07-21 | |||
| US20170216457A1 | 2017-08-03 | |||
| US20180064749A1 | 2018-03-08 |
Other References:
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SOCHEATA LY ET AL: "Visualization of self-delivering hydrophobically modified siRNA cellular internalization", NUCLEIC ACIDS RESEARCH, vol. 45, no. 1, 29 November 2016 (2016-11-29), GB, pages 15 - 25, XP055752164, ISSN: 0305-1048, DOI: 10.1093/nar/gkw1005
YOSHINAGA NAOTO ET AL: "Induced packaging of mRNA into polyplex micelles by regulated hybridization with a small number of cholesteryl RNA oligonucleotides directed enhanced in vivo transfection", BIOMATERIALS, vol. 197, 17 January 2019 (2019-01-17), AMSTERDAM, NL, pages 255 - 267, XP055782586, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2019.01.023
COOLEN ANNE-LINE ET AL: "Poly(lactic acid) nanoparticles and cell-penetrating peptide potentiate mRNA-based vaccine expression in dendritic cells triggering their activation", BIOMATERIALS, vol. 195, 21 December 2018 (2018-12-21), AMSTERDAM, NL, pages 23 - 37, XP055782195, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2018.12.019
YANEZ ARTETA MARIANNA ET AL: "Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 115, no. 15, 27 March 2018 (2018-03-27), US, pages E3351 - E3360, XP055782146, ISSN: 0027-8424, Retrieved from the Internet DOI: 10.1073/pnas.1720542115
LIU JIANBING ET AL: "A DNA-Based Nanocarrier for Efficient Gene Delivery and Combined Cancer Therapy", NANO LETTERS, vol. 18, no. 6, 30 April 2018 (2018-04-30), US, pages 3328 - 3334, XP055782243, ISSN: 1530-6984, Retrieved from the Internet DOI: 10.1021/acs.nanolett.7b04812
SOCHEATA LY ET AL: "Visualization of self-delivering hydrophobically modified siRNA cellular internalization", NUCLEIC ACIDS RESEARCH, vol. 45, no. 1, 29 November 2016 (2016-11-29), GB, pages 15 - 25, XP055752164, ISSN: 0305-1048, DOI: 10.1093/nar/gkw1005
YOSHINAGA NAOTO ET AL: "Induced packaging of mRNA into polyplex micelles by regulated hybridization with a small number of cholesteryl RNA oligonucleotides directed enhanced in vivo transfection", BIOMATERIALS, vol. 197, 17 January 2019 (2019-01-17), AMSTERDAM, NL, pages 255 - 267, XP055782586, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2019.01.023
COOLEN ANNE-LINE ET AL: "Poly(lactic acid) nanoparticles and cell-penetrating peptide potentiate mRNA-based vaccine expression in dendritic cells triggering their activation", BIOMATERIALS, vol. 195, 21 December 2018 (2018-12-21), AMSTERDAM, NL, pages 23 - 37, XP055782195, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2018.12.019
YANEZ ARTETA MARIANNA ET AL: "Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 115, no. 15, 27 March 2018 (2018-03-27), US, pages E3351 - E3360, XP055782146, ISSN: 0027-8424, Retrieved from the Internet
LIU JIANBING ET AL: "A DNA-Based Nanocarrier for Efficient Gene Delivery and Combined Cancer Therapy", NANO LETTERS, vol. 18, no. 6, 30 April 2018 (2018-04-30), US, pages 3328 - 3334, XP055782243, ISSN: 1530-6984, Retrieved from the Internet
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