Title:
COMPOSITIONS FOR TREATING PARKINSON'S DISEASE
Document Type and Number:
WIPO Patent Application WO/2014/037416
Kind Code:
A3
Abstract:
The present invention relates to compositions and methods for the treatment of Parkinson's disease and related disorders. More specifically, the present invention relates to novel combinatorial therapies of Parkinson's disease and related disorders targeting the alpha-synuclein aggregation network. In particular, the invention relates to compounds which, alone or in combination(s), can effectively protect neuronal cells from alpha- synuclein aggregates. The invention also relates to methods of producing a drug or a drug combination for treating Parkinson's disease and to methods of treating Parkinson's disease or a related disorder.
Inventors:
COHEN DANIEL (FR)
NABIROCHKIN SERGUEI (FR)
CHUMAKOV ILYA (FR)
NABIROCHKIN SERGUEI (FR)
CHUMAKOV ILYA (FR)
Application Number:
PCT/EP2013/068312
Publication Date:
May 01, 2014
Filing Date:
September 04, 2013
Export Citation:
Assignee:
PHARNEXT (FR)
International Classes:
A61K31/135; A61K31/13; A61K31/137; A61K31/138; A61K31/155; A61K31/165; A61K31/185; A61K31/192; A61K31/195; A61K31/197; A61K31/198; A61K31/24; A61K31/27; A61K31/343; A61K31/353; A61K31/403
Domestic Patent References:
| WO2008089212A1 | 2008-07-24 | |||
| WO2012076555A1 | 2012-06-14 | |||
| WO2012067621A1 | 2012-05-24 | |||
| WO2002056892A2 | 2002-07-25 | |||
| WO2012117073A2 | 2012-09-07 |
Foreign References:
| US20090076019A1 | 2009-03-19 | |||
| EP2322163A1 | 2011-05-18 | |||
| US5677344A | 1997-10-14 |
Other References:
SUZUKI YOKO ET AL: "Antioxidant properties of carvedilol: Inhibition of lipid peroxidation, protein oxidation and superoxide generation", NEUROLOGICAL RESEARCH, MANEY PUBLISHING, GB, vol. 25, no. 7, 1 October 2003 (2003-10-01), pages 749 - 753, XP008165757, ISSN: 0161-6412
"Therapeutic Category and Biological Activity Index: ANTIPARKINSONIAN ED - MARYADELE J O'NEIL (; ET AL) (EDS)", THE MERCK INDEX. AN ENCYCLOPEDIA OF CHEMICALS, DRUGS, AND BIOLOGICALS, WHITEHOUSE STATION, NJ, USA, 1 January 2006 (2006-01-01), pages 15, XP002688415, ISBN: 978-0-911910-00-1
KENNETH A FOLLETT ET AL: "Pallidal versus subthalamic deep-brain stimulation for Parkinson's disease", NEW ENGLAND JOURNAL OF MEDICINE, MASSACHUSETTS MEDICAL SOCIETY, BOSTON, MA, US, vol. 362, no. 22, 3 June 2010 (2010-06-03), pages 2077 - 2091, XP002688416, ISSN: 1533-4406, [retrieved on 20110302], DOI: 10.1056/NEJMOA0907083
"Therapeutic Category and Biological Activity Index: ANTIPARKINSONIAN ED - MARYADELE J O'NEIL (; ET AL) (EDS)", THE MERCK INDEX. AN ENCYCLOPEDIA OF CHEMICALS, DRUGS, AND BIOLOGICALS, WHITEHOUSE STATION, NJ, USA, 1 January 2006 (2006-01-01), pages 15, XP002688415, ISBN: 978-0-911910-00-1
KENNETH A FOLLETT ET AL: "Pallidal versus subthalamic deep-brain stimulation for Parkinson's disease", NEW ENGLAND JOURNAL OF MEDICINE, MASSACHUSETTS MEDICAL SOCIETY, BOSTON, MA, US, vol. 362, no. 22, 3 June 2010 (2010-06-03), pages 2077 - 2091, XP002688416, ISSN: 1533-4406, [retrieved on 20110302], DOI: 10.1056/NEJMOA0907083
Attorney, Agent or Firm:
BECKER, Philippe et al. (25 rue Louis Le Grand, Paris, FR)
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