Title:
COMPOSITIONS OF WET ADHESIVES DERIVED FROM VIBRIO CHOLERAE BIOFILM ADHESINS AND METHODS THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/064752
Kind Code:
A3
Abstract:
Bio-adhesive derived from Vibrio cholerae (Vc) are provided. In some forms, the bio-adhesive includes a sequence of 57 amino acids within a major biofilm adhesin Bap1, and sequence variations thereof, that can be used as bioactive glue to adhere to various surfaces with different chemistries. Methods of producing and using the peptides are also provided.
Inventors:
YAN JING (US)
OLSON III RICHARD ARON (US)
OLSON III RICHARD ARON (US)
Application Number:
PCT/US2023/074691
Publication Date:
May 02, 2024
Filing Date:
September 20, 2023
Export Citation:
Assignee:
UNIV YALE (US)
WESLEYAN UNIV (US)
WESLEYAN UNIV (US)
International Classes:
C07K14/28; A61K39/02; C12N1/20; C12N15/31; C12N15/62
Domestic Patent References:
| WO2019228291A1 | 2019-12-05 |
Other References:
DATABASE UniProt [online] EBI; 14 October 2015 (2015-10-14), NOORANI M.: "Hemolysin-like protein", XP002810805, retrieved from EBI accession no. A0A0H8UXH5 Database accession no. A0A0H8UXH5
DATABASE UniProt [online] EBI; 19 January 2022 (2022-01-19), HANSEN M.J., DALSGAARD I.: "Hemolysin fragment", XP002810806, retrieved from EBI accession no. A0A8I0V4I8 Database accession no. A0A8I0V4I8
DATABASE UniProt [online] EBI; 17 June 2020 (2020-06-17), ABDULABBAS H.T. ET AL.: "Hemolysin fragment", XP002810807, retrieved from EBI accession no. A0A6B3LGT5 Database accession no. A0A6B3LGT5
DATABASE UniProt [online] EBI; 25 October 2017 (2017-10-25), GONG L.: "Hemolysin", XP002810808, retrieved from EBI accession no. A0A223MWP1 Database accession no. A0A223MWP1
CHAO ZHONG ET AL: "Strong underwater adhesives made by self-assembling multi-protein nanofibres", NATURE NANOTECHNOLOGY, vol. 9, no. 10, 21 September 2014 (2014-09-21), pages 858 - 866, XP055208249, ISSN: 1748-3387, DOI: 10.1038/nnano.2014.199
LEVAN SOPHIA ET AL: "Vibrio cholerae Cytolysin Recognizes the Heptasaccharide Core of Complex N-Glycans with Nanomolar Affinity", JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS, UNITED KINGDOM, vol. 425, no. 5, 28 December 2012 (2012-12-28), pages 944 - 957, XP028981589, ISSN: 0022-2836, DOI: 10.1016/J.JMB.2012.12.016
DE SWASTIK ET AL: "Structural basis of mammalian glycan targeting by Vibrio cholerae cytolysin and biofilm proteins", PLOS PATHOGENS, vol. 14, no. 2, 12 February 2018 (2018-02-12), US, pages e1006841, XP093116919, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1006841
DATABASE UniProt [online] EBI; 19 January 2022 (2022-01-19), HANSEN M.J., DALSGAARD I.: "Hemolysin fragment", XP002810806, retrieved from EBI accession no. A0A8I0V4I8 Database accession no. A0A8I0V4I8
DATABASE UniProt [online] EBI; 17 June 2020 (2020-06-17), ABDULABBAS H.T. ET AL.: "Hemolysin fragment", XP002810807, retrieved from EBI accession no. A0A6B3LGT5 Database accession no. A0A6B3LGT5
DATABASE UniProt [online] EBI; 25 October 2017 (2017-10-25), GONG L.: "Hemolysin", XP002810808, retrieved from EBI accession no. A0A223MWP1 Database accession no. A0A223MWP1
CHAO ZHONG ET AL: "Strong underwater adhesives made by self-assembling multi-protein nanofibres", NATURE NANOTECHNOLOGY, vol. 9, no. 10, 21 September 2014 (2014-09-21), pages 858 - 866, XP055208249, ISSN: 1748-3387, DOI: 10.1038/nnano.2014.199
LEVAN SOPHIA ET AL: "Vibrio cholerae Cytolysin Recognizes the Heptasaccharide Core of Complex N-Glycans with Nanomolar Affinity", JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS, UNITED KINGDOM, vol. 425, no. 5, 28 December 2012 (2012-12-28), pages 944 - 957, XP028981589, ISSN: 0022-2836, DOI: 10.1016/J.JMB.2012.12.016
DE SWASTIK ET AL: "Structural basis of mammalian glycan targeting by Vibrio cholerae cytolysin and biofilm proteins", PLOS PATHOGENS, vol. 14, no. 2, 12 February 2018 (2018-02-12), US, pages e1006841, XP093116919, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1006841
Attorney, Agent or Firm:
RAYMOND, Adam S. et al. (US)
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