Title:
COMPOUND FOR AGGREGATION-INDUCED EMISSION, COMPOSITION FOR CELL IMAGING USING SAME, AND USE AS CELL-IMAGING CONTRAST AGENT
Document Type and Number:
WIPO Patent Application WO/2022/065938
Kind Code:
A1
Abstract:
The present invention relates to a compound for aggregation-induced emission and a composition for cell imaging using same and, more specifically, to an indolizine molecular framework-based compound for aggregation-induced emission, a mitochondria-targeting complex in which the compound for aggregation-induced emission and a mitochondria-targeting material are bound, and a cell-imaging composition using same. In the present invention, indolizine framework-based, novel aggregation-induced emission luminogens, which have a systematic structure to emit luminescence wavelengths of all colors through a change in electron density at a specific site in molecules, were synthesized, and it was confirmed that, when these luminogens are used in combination with a mitochondria-targeting material, the mitochondria of cells is stained and effective cell imaging is possible without an additional washing process. Therefore, the novel aggregation-induced emission luminogens of the present invention can be utilized usefully in diverse cell imaging.
Inventors:
KIM EUN HA (KR)
CHOI SANG KEE (KR)
CHOI SANG KEE (KR)
Application Number:
PCT/KR2021/013094
Publication Date:
March 31, 2022
Filing Date:
September 27, 2021
Export Citation:
Assignee:
AJOU UNIV INDUSTRY ACADEMIC COOPERATION FOUNDATIO (KR)
International Classes:
C09K11/06; G01N21/64; G01N31/22
Foreign References:
| GB765874A | 1957-01-16 |
Other References:
EUNHA KIM, OH SEONG-GEUN: "Development of fluorescent pharmacophore and biomedical application", FINAL REPORT. MINISTRY OF SCIENCE AND ICT, 1 June 2019 (2019-06-01), Korea, pages 1 - 33, XP009536038
SK BAHADUR, PATRA ABHIJIT: "C–C coupling over Schiff base condensation: a rational design strategy for a strongly fluorescent molecular material", CRYSTENGCOMM, vol. 18, no. 23, 1 January 2016 (2016-01-01), pages 4290 - 4294, XP055914327, DOI: 10.1039/C5CE02489G
CARTER PHILLIP W., DIMAGNO STEPHEN G., PORTER JOHN D., STREITWIESER ANDREW: ".pi.-Stacking and aggregation of pyridinium-substituted indolizines", THE JOURNAL OF PHYSICAL CHEMISTRY, vol. 97, no. 5, 1 February 1993 (1993-02-01), pages 1085 - 1096, XP055914338, ISSN: 0022-3654, DOI: 10.1021/j100107a017
CHOI SANG-KEE, RHO JUNGI, YOON SANG EUN, SEOK JIN-HONG, KIM HYUNGI, MIN JUNSIK, YOON WOOJIN, LEE SANGHEE, YUN HOSEOP, KWON O-PIL, : "Full Color Tunable Aggregation-Induced Emission Luminogen for Bioimaging Based on an Indolizine Molecular Framework", BIOCONJUGATE CHEMISTRY, vol. 31, no. 11, 18 November 2020 (2020-11-18), US , pages 2522 - 2532, XP055914342, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.0c00467
SK BAHADUR, PATRA ABHIJIT: "C–C coupling over Schiff base condensation: a rational design strategy for a strongly fluorescent molecular material", CRYSTENGCOMM, vol. 18, no. 23, 1 January 2016 (2016-01-01), pages 4290 - 4294, XP055914327, DOI: 10.1039/C5CE02489G
CARTER PHILLIP W., DIMAGNO STEPHEN G., PORTER JOHN D., STREITWIESER ANDREW: ".pi.-Stacking and aggregation of pyridinium-substituted indolizines", THE JOURNAL OF PHYSICAL CHEMISTRY, vol. 97, no. 5, 1 February 1993 (1993-02-01), pages 1085 - 1096, XP055914338, ISSN: 0022-3654, DOI: 10.1021/j100107a017
CHOI SANG-KEE, RHO JUNGI, YOON SANG EUN, SEOK JIN-HONG, KIM HYUNGI, MIN JUNSIK, YOON WOOJIN, LEE SANGHEE, YUN HOSEOP, KWON O-PIL, : "Full Color Tunable Aggregation-Induced Emission Luminogen for Bioimaging Based on an Indolizine Molecular Framework", BIOCONJUGATE CHEMISTRY, vol. 31, no. 11, 18 November 2020 (2020-11-18), US , pages 2522 - 2532, XP055914342, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.0c00467
Attorney, Agent or Firm:
ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM (KR)
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