Title:
COMPOUND AS AKT KINASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2022/068917
Kind Code:
A1
Abstract:
Provided is a compound as an Akt kinase inhibitor. The present invention specifically relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, a preparation method therefor, a pharmaceutical composition containing the compound, and the use thereof in the preparation of a drug for treating Akt kinase-related diseases.
Inventors:
ZHANG YINSHENG (CN)
GAO YONG (CN)
SHI WEI (CN)
ZHAO DAMIN (CN)
YIN YUAN (CN)
GAO YONG (CN)
SHI WEI (CN)
ZHAO DAMIN (CN)
YIN YUAN (CN)
Application Number:
PCT/CN2021/122040
Publication Date:
April 07, 2022
Filing Date:
September 30, 2021
Export Citation:
Assignee:
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN)
International Classes:
C07D471/04; A61K31/437; A61K31/444; A61P35/00; C07D413/14; C07D417/14; C07D487/04
Domestic Patent References:
| WO2011082270A2 | 2011-07-07 | |||
| WO2012177852A1 | 2012-12-27 | |||
| WO2012177844A2 | 2012-12-27 | |||
| WO2016037044A1 | 2016-03-10 |
Other References:
MARK A. ASHWELL, JEAN-MARC LAPIERRE, CHRISTOPHER BRASSARD, KAREN BRESCIANO, CATHY BULL, SUSAN CORNELL-KENNON, SUDHARSHAN EATHIRAJ,: "Discovery and Optimization of a Series of 3-(3-Phenyl-3 H -imidazo[4,5- b ]pyridin-2-yl)pyridin-2-amines: Orally Bioavailable, Selective, and Potent ATP-Independent Akt Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, no. 11, 14 June 2012 (2012-06-14), pages 5291 - 5310, XP055076710, ISSN: 0022-2623, DOI: 10.1021/jm300276x
JEAN-MARC LAPIERRE, SUDHARSHAN EATHIRAJ, DAVID VENSEL, YANBIN LIU, CATHY O. BULL, SUSAN CORNELL-KENNON, SHIN IIMURA, EUGENE W. KEL: "Discovery of 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3 H -imidazo[4,5- b ]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor", JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, no. 13, 14 July 2016 (2016-07-14), US , pages 6455 - 6469, XP055529597, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.6b00619
"Greene 's Protective Groups in Organic Synthesis", JOHN WILEY & SONS, INC.
JEAN-MARC LAPIERRE, SUDHARSHAN EATHIRAJ, DAVID VENSEL, YANBIN LIU, CATHY O. BULL, SUSAN CORNELL-KENNON, SHIN IIMURA, EUGENE W. KEL: "Discovery of 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3 H -imidazo[4,5- b ]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor", JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, no. 13, 14 July 2016 (2016-07-14), US , pages 6455 - 6469, XP055529597, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.6b00619
"Greene 's Protective Groups in Organic Synthesis", JOHN WILEY & SONS, INC.
Attorney, Agent or Firm:
INSIGHT INTELLECTUAL PROPERTY LIMITED (CN)
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