Title:
COMPOUND BASED ON ISOINDOLINE-SUBSTITUTED GLUTARIMIDE BACKBONE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/032689
Kind Code:
A1
Abstract:
The present disclosure relates to a compound of formula (I) or a salt thereof, an enantiomer thereof, a stereoisomer thereof, a solvate thereof, or a polymorph thereof, and use thereof. The present disclosure further relates to a pharmaceutical composition comprising a compound of formula (I) or a salt thereof, an enantiomer thereof, a stereoisomer thereof, a solvate thereof, or a polymorph thereof as an active ingredient, and use thereof. A series of compounds designed and synthesized by the present disclosure can effectively prevent and/or treat diseases or conditions related to the protein cereblon.
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Inventors:
YANG XIAOBAO (CN)
SUN RENHONG (CN)
ZHOU YUEDONG (CN)
ZHAO BAOYIN (CN)
SUN RENHONG (CN)
ZHOU YUEDONG (CN)
ZHAO BAOYIN (CN)
Application Number:
PCT/CN2023/112130
Publication Date:
February 15, 2024
Filing Date:
August 10, 2023
Export Citation:
Assignee:
GLUETACS THERAPEUTICS SHANGHAI CO LTD (CN)
International Classes:
C07D401/04; A61K31/454; A61K31/4545; A61P35/00; C07D401/14; C07D471/04; C07D487/04
Domestic Patent References:
| WO2022232536A1 | 2022-11-03 | |||
| WO2021173995A2 | 2021-09-02 | |||
| WO2020160198A1 | 2020-08-06 | |||
| WO2021022163A2 | 2021-02-04 |
Foreign References:
| CN111051298A | 2020-04-21 | |||
| CN111629749A | 2020-09-04 | |||
| CN114650868A | 2022-06-21 |
Attorney, Agent or Firm:
SYNCLAW ATTORNEYS (CN)
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