Title:
COMPOUND, ENDOTHELIN-A RECEPTOR ANTAGONIST, AND PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2022/270487
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a compound having an ETA receptor antagonistic activity and others. The problem can be solved by a compound represented by formula (1) [wherein variables are as defined in the description] or a pharmaceutically acceptable salt thereof.
Inventors:
TANAKA KEIGO (JP)
NINOMIYA TOMOHISA (JP)
TOMATA YOSHIHIDE (JP)
NINOMIYA TOMOHISA (JP)
TOMATA YOSHIHIDE (JP)
Application Number:
PCT/JP2022/024638
Publication Date:
December 29, 2022
Filing Date:
June 21, 2022
Export Citation:
Assignee:
ALCHEMEDICINE INC (JP)
International Classes:
C07D405/14; A61K31/4439; A61P1/16; A61P9/08; A61P9/12; A61P11/00; A61P13/12; A61P25/02; A61P35/00; A61P43/00; C07D413/14
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PHARMACOLOGICAL REVIEWS, vol. 68, 2016, pages 357 - 418
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, vol. 47, 2007, pages 731 - 759
INTERNATIONAL HEART JOURNAL, vol. 61, 2020, pages 799 - 805
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 29, 2018, pages 2745 - 2754
NEPHRON, vol. 72, 1996, pages 454 - 460
THE LANCET, vol. 393, 2019, pages 1937 - 1947
HYPERTENSION, vol. 57, 2011, pages 772 - 779
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 28, 2017, pages 2443 - 2458
TRANSPLANTATION, vol. 71, 2001, pages 211 - 216
HYPERTENSION, vol. 52, 2008, pages 452 - 459
DRUG RESEARCH, vol. 65, 2015, pages 272 - 280
WORLD JOURNAL OF HEPATOLOGY, vol. 8, 2016, pages 933 - 941
DIGESTIVE DISEASES AND SCIENCES, vol. 52, 2007, pages 2622 - 2628
NATURE REVIEWS CANCER, vol. 13, 2013, pages 637 - 651
EUROPEAN JOURNAL OF PAIN, vol. 22, 2018, pages 501 - 510
FERTILITY AND STERILITY, vol. 61, 1994, pages 1083 - 1087
INFLAMMATION ALLERGY - DRUG TARGETS, vol. 10, 2011, pages 19 - 26
ANNALS OF THE RHEUMATIC DISEASES, vol. 70, 2011, pages 32 - 38
MOLECULAR MEDICINE REPORTS, vol. 18, 2018, pages 5229 - 5236
JOURNAL OF THE AMERICAN HEART ASSOCIATION, vol. 3, 2014, pages e00126
EUROPEAN HEART JOURNAL, vol. 29, 2008, pages 1936 - 1948
PHARMACOLOGICAL REVIEWS, vol. 68, 2016, pages 357 - 418
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, vol. 47, 2007, pages 731 - 759
Attorney, Agent or Firm:
INABA, Yoshiyuki et al. (JP)
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