Title:
COMPOUND, FOLATE RECEPTOR VISUALIZATION FLUORESCENT PROBE, AND USE OF THESE
Document Type and Number:
WIPO Patent Application WO/2018/101473
Kind Code:
A1
Abstract:
A compound represented by general formula (1). (In the formula, X is SiR2, GeR2, SnR2, CR2, SO2, or POR'. The abovementioned R is a C1-10 alkyl group. The abovementioned R' is a C1-10 alkyl group, hydroxyl group, or phenyl group. R11, R12, R13, R14, R15, R16, and R17 each independently are a hydrogen atom, a halogen atom, a C1-10 alkyl group, a C1-10 alkoxy group, a C1-10 hydroxyalkyl group, a hydroxyl group, a carboxy group, an amino group, or an amide group. R12 and R13, and R16 and R17, may connect to each other to form a ring. R18 is a group represented by formula (2). n11 is an integer of 1-4. n12 and n13 are integers of 1-3.)
Inventors:
HANAOKA KENJIRO (JP)
URANO YASUTERU (JP)
NUMASAWA KOJI (JP)
IKENO TAKAYUKI (JP)
HOSHINO YUKI (JP)
URANO YASUTERU (JP)
NUMASAWA KOJI (JP)
IKENO TAKAYUKI (JP)
HOSHINO YUKI (JP)
Application Number:
PCT/JP2017/043357
Publication Date:
June 07, 2018
Filing Date:
December 01, 2017
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
C07F7/10; A61K49/00; B82Y15/00
Domestic Patent References:
| WO2012111818A1 | 2012-08-23 |
Foreign References:
| JP2016512814A | 2016-05-09 | |||
| US20100226967A1 | 2010-09-09 | |||
| US20120003151A1 | 2012-01-05 | |||
| JP2014157150A | 2014-08-28 |
Other References:
JSMI REPORT, vol. 8, 25 November 2014 (2014-11-25), pages 28 - 38
YANG, J. ET AL.: "Evaluation of disulfide reduction during receptor-mediated endocytosis by using FRET imaging", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 103, no. 37, 12 September 2006 (2006-09-12), pages 13872 - 13877, XP002519657
YANG, J. J. ET AL.: "Characterrization of in vivo disulfide-reduction mediated drug release in mouse kidneys", MOLECULAR PHARMACEUTICS, vol. 9, no. 2, 9 January 2012 (2012-01-09), pages 310 - 317, XP055513782
YANG, J. ET AL.: "Characterization of the pH of folate receptor-containing endosomes and the rate of hydrolysis of internalized acid-labile folate-drug conjugates", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 321, no. 2, 8 February 2007 (2007-02-08), pages 462 - 468, XP002730837
YANG, J. ET AL.: "Evaluation of disulfide reduction during receptor-mediated endocytosis by using FRET imaging", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 103, no. 37, 12 September 2006 (2006-09-12), pages 13872 - 13877, XP002519657
YANG, J. J. ET AL.: "Characterrization of in vivo disulfide-reduction mediated drug release in mouse kidneys", MOLECULAR PHARMACEUTICS, vol. 9, no. 2, 9 January 2012 (2012-01-09), pages 310 - 317, XP055513782
YANG, J. ET AL.: "Characterization of the pH of folate receptor-containing endosomes and the rate of hydrolysis of internalized acid-labile folate-drug conjugates", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 321, no. 2, 8 February 2007 (2007-02-08), pages 462 - 468, XP002730837
Attorney, Agent or Firm:
TANAI Sumio et al. (JP)
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