Title:
COMPOUND HAVING ACYLAMINOPHENYL GROUP, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/084870
Kind Code:
A1
Abstract:
Provided is an acylaminophenyl-group-containing compound having a neuroprotective effect. Also provided is a neuroprotective agent including an acylaminophenyl-group-containing compound. A novel acylaminophenyl-group-containing compound, and neural cells are protected and cell death of neural cells is minimized by using an acylaminophenyl-group-containing compound.
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Inventors:
MOCHIZUKI HIDEKI (JP)
SASAKI TSUTOMU (JP)
CHOONG CHI JING (JP)
UESATO SHINICHI (JP)
SASAKI TSUTOMU (JP)
CHOONG CHI JING (JP)
UESATO SHINICHI (JP)
Application Number:
PCT/JP2015/083139
Publication Date:
June 02, 2016
Filing Date:
November 25, 2015
Export Citation:
Assignee:
UNIV OSAKA (JP)
SCHOOL CORP KANSAI UNIV (JP)
SCHOOL CORP KANSAI UNIV (JP)
International Classes:
A61K31/167; A61K31/17; A61K31/215; A61K31/40; A61K31/4025; A61K31/444; A61K31/4453; A61K31/496; A61P21/00; A61P25/00; A61P25/16; A61P25/28; C07C323/37; C07C327/22; C07D213/82; C07D241/08; C07D295/215
Foreign References:
| JPH0223338A | 1990-01-25 | |||
| JP2007039486A | 2007-02-15 | |||
| JP2011178704A | 2011-09-15 | |||
| JPH095926A | 1997-01-10 |
Other References:
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NAIK, SARALA ET AL.: "Chemoselective Acylation of Amines in Aqueous Media", EUR. J. ORG. CHEM., vol. 2004, no. 6, 2004, pages 1254 - 1260
KHALIGH, NADER GHAFFARI ET AL.: "Poly(N-vinylimidazole) as an efficient catalyst for acetylation of alcohols, phenols, thiols and amines under solvent-free conditions", RSC ADV., vol. 3, 2013, pages 99 - 110
SHINKAI, HISASHI ET AL.: "Bis(2-(Acylamino) phenyl) Disulfides, 2-(Acylamino)benzenethiols, and S-(2-(Acylamino)phenyl) Alkanethioates as Novel Inhibitors of Cholesteryl Ester Transfer Protein", J. MED. CHEM., vol. 2000, no. 43, 2000, pages 3566 - 3572
WEINSTEIN, ARTHUR H. ET AL.: "Preparation of Symmetrical Diaryl Disulfides Containing Side ChainsTerminated by Halogen or by Tertiary Amino Functions", SYMMETRICALLY SUBSTITUTED DIARYL DISULFIDES, vol. 23, no. 3, 1958, pages 363 - 372
COATES, ROBERT M. ET AL.: "Decarboxylative 1- Aza-1 '-oxa [3,3]Sigmatropic Rearrangements of Enolizable or Enolized N-Aryl-N,O- diacylhydroxylamines to o-(N-Acylamino)aryl Ketones, Esters, and Amides:a New Synthetic Method for Ortho Alkylation", JACS, vol. 99, no. 7, 1977, pages 2355 - 2357
WITKOP, BERNHARD ET AL.: "Acid- and Base- catalyzed Rearrangements of a Ring-Chain Tautomeric Ozonide", JACS, vol. 74, no. 15, 1952, pages 3861 - 3866
WANG, DONGREN ET AL.: "Formation, Preservation, and Cleavage of the Disulfide Bond by Vanadium", CHEM. EUR. J., vol. 9, no. 8, 2003, pages 1805 - 1813
SARKAR, SHURANJAN ET AL.: "N,N'-(Ethane-1,2- diyldi-o-phenylene)-bis(pyridine-2-carboxamide", ACTA CRYST., vol. 67, no. 11, 2011, pages o2988
ANDERSON, BRADLEY D. ET AL.: "Prostaglandin Prodrugs VI: Structure-Thermodynamic Activity and Structure-Aqueous Solubility Relationships", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 69, no. 4, 1980, pages 424 - 430
RANER, KEVIN D.: "Reactions of Epoxides Derived From 2'-(3''-Methylbut-2''-enyl) trifluoroacetanilides", AUST. J. CHEM., vol. 43, no. 3, 1990, pages 609 - 616
NAIK, SARALA ET AL.: "Chemoselective Acylation of Amines in Aqueous Media", EUR. J. ORG. CHEM., vol. 2004, no. 6, 2004, pages 1254 - 1260
KHALIGH, NADER GHAFFARI ET AL.: "Poly(N-vinylimidazole) as an efficient catalyst for acetylation of alcohols, phenols, thiols and amines under solvent-free conditions", RSC ADV., vol. 3, 2013, pages 99 - 110
SHINKAI, HISASHI ET AL.: "Bis(2-(Acylamino) phenyl) Disulfides, 2-(Acylamino)benzenethiols, and S-(2-(Acylamino)phenyl) Alkanethioates as Novel Inhibitors of Cholesteryl Ester Transfer Protein", J. MED. CHEM., vol. 2000, no. 43, 2000, pages 3566 - 3572
WEINSTEIN, ARTHUR H. ET AL.: "Preparation of Symmetrical Diaryl Disulfides Containing Side ChainsTerminated by Halogen or by Tertiary Amino Functions", SYMMETRICALLY SUBSTITUTED DIARYL DISULFIDES, vol. 23, no. 3, 1958, pages 363 - 372
COATES, ROBERT M. ET AL.: "Decarboxylative 1- Aza-1 '-oxa [3,3]Sigmatropic Rearrangements of Enolizable or Enolized N-Aryl-N,O- diacylhydroxylamines to o-(N-Acylamino)aryl Ketones, Esters, and Amides:a New Synthetic Method for Ortho Alkylation", JACS, vol. 99, no. 7, 1977, pages 2355 - 2357
WITKOP, BERNHARD ET AL.: "Acid- and Base- catalyzed Rearrangements of a Ring-Chain Tautomeric Ozonide", JACS, vol. 74, no. 15, 1952, pages 3861 - 3866
WANG, DONGREN ET AL.: "Formation, Preservation, and Cleavage of the Disulfide Bond by Vanadium", CHEM. EUR. J., vol. 9, no. 8, 2003, pages 1805 - 1813
SARKAR, SHURANJAN ET AL.: "N,N'-(Ethane-1,2- diyldi-o-phenylene)-bis(pyridine-2-carboxamide", ACTA CRYST., vol. 67, no. 11, 2011, pages o2988
ANDERSON, BRADLEY D. ET AL.: "Prostaglandin Prodrugs VI: Structure-Thermodynamic Activity and Structure-Aqueous Solubility Relationships", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 69, no. 4, 1980, pages 424 - 430
RANER, KEVIN D.: "Reactions of Epoxides Derived From 2'-(3''-Methylbut-2''-enyl) trifluoroacetanilides", AUST. J. CHEM., vol. 43, no. 3, 1990, pages 609 - 616
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
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